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Scientific article
Open access
English

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

Published inDiabetologia, vol. 54, no. 2, p. 360-367
Publication date2011
Abstract

Although recent studies propose that epigenetic factors influence insulin expression, the regulation of the insulin gene in type 2 diabetic islets is still not fully understood. Here, we examined DNA methylation of the insulin gene promoter in pancreatic islets from patients with type 2 diabetes and non-diabetic human donors and related it to insulin expression, HbA(1c) levels, BMI and age.

Keywords
  • Animals
  • Cell Line
  • DNA Methylation/genetics/physiology
  • Humans
  • Insulin/genetics/metabolism
  • Insulin-Secreting Cells/metabolism
  • Islets of Langerhans/metabolism
  • Promoter Regions, Genetic/genetics
  • Rats
Citation (ISO format)
YANG, B T et al. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. In: Diabetologia, 2011, vol. 54, n° 2, p. 360–367. doi: 10.1007/s00125-010-1967-6
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0012-186X
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