Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets
ContributorsYang, B T; Dayeh, T A; Kirkpatrick, Clare; Taneera, J; Kumar, R; Groop, L; Wollheim, Claes; Nitert, M D; Ling, C
Published inDiabetologia, vol. 54, no. 2, p. 360-367
Publication date2011
Abstract
Keywords
- Animals
- Cell Line
- DNA Methylation/genetics/physiology
- Humans
- Insulin/genetics/metabolism
- Insulin-Secreting Cells/metabolism
- Islets of Langerhans/metabolism
- Promoter Regions, Genetic/genetics
- Rats
Citation (ISO format)
YANG, B T et al. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. In: Diabetologia, 2011, vol. 54, n° 2, p. 360–367. doi: 10.1007/s00125-010-1967-6
Main files (1)
Article (Published version)
Identifiers
- PID : unige:33552
- DOI : 10.1007/s00125-010-1967-6
- PMID : 21104225
ISSN of the journal0012-186X