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Title

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

Authors
Bonner, Caroline
Bacon, Siobhán
Concannon, Caoimhín G
Rizvi, Syed R
Farrelly, Angela M
Kilbride, Seán M
Dussmann, Heiko
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Published in Diabetes. 2010, vol. 59, no. 11, p. 2799-808
Abstract In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased β-cell mass and HNF1A-maturity onset diabetes of the young (HNF1A-MODY). Here, we investigated the effect of a dominant-negative HNF1A mutant (DN-HNF1A) induced apoptosis on the regenerative capacity of INS-1 cells.
Keywords AnimalsApoptosisCaspase 3/metabolismCaspases/genetics/pharmacologyCell Death/drug effectsDiabetes Mellitus, Type 2/genetics/physiopathologyEnzyme-Linked Immunosorbent AssayHepatocyte Nuclear Factor 1-alpha/genetics/pharmacologyHumansInsulin-Secreting Cells/cytology/drug effects/physiologyInsulinoma/geneticsMiceMice, Inbred C57BLMice, TransgenicPromoter Regions, GeneticRatsReverse Transcriptase Polymerase Chain Reaction
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PMID: 20682686
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BONNER, Caroline et al. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. In: Diabetes, 2010, vol. 59, n° 11, p. 2799-808. doi: 10.2337/db09-1478 https://archive-ouverte.unige.ch/unige:33550

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Deposited on : 2014-01-22

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