INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

Bonner, Caroline; Bacon, Siobhán; Concannon, Caoimhín G; Rizvi, Syed R; Baquie, Mathurin; Farrelly, Angela M; Kilbride, Seán M; Dussmann, Heiko; Ward, Manus W; Boulanger, Chantal M; Wollheim, Claes; Graf, Rolf; Byrne, Maria M; Prehn, Jochen H M

doi:10.2337/db09-1478

Scientific article

Open access

English

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

ContributorsBonner, Caroline; Bacon, Siobhán; Concannon, Caoimhín G; Rizvi, Syed R; Baquie, Mathurin; Farrelly, Angela M; Kilbride, Seán M; Dussmann, Heiko; Ward, Manus W; Boulanger, Chantal M; Wollheim, Claes; Graf, Rolf; Byrne, Maria M; Prehn, Jochen H M

Published inDiabetes, vol. 59, no. 11, p. 2799-2808

Publication date2010

Abstract

In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased β-cell mass and HNF1A-maturity onset diabetes of the young (HNF1A-MODY). Here, we investigated the effect of a dominant-negative HNF1A mutant (DN-HNF1A) induced apoptosis on the regenerative capacity of INS-1 cells.

Keywords

Animals
Apoptosis
Caspase 3/metabolism
Caspases/genetics/pharmacology
Cell Death/drug effects
Diabetes Mellitus, Type 2/genetics/physiopathology
Enzyme-Linked Immunosorbent Assay
Hepatocyte Nuclear Factor 1-alpha/genetics/pharmacology
Humans
Insulin-Secreting Cells/cytology/drug effects/physiology
Insulinoma/genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Promoter Regions, Genetic
Rats
Reverse Transcriptase Polymerase Chain Reaction

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Citation (ISO format)

BONNER, Caroline et al. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. In: Diabetes, 2010, vol. 59, n° 11, p. 2799–2808. doi: 10.2337/db09-1478

Article (Published version)

Identifiers

PID : unige:33550
DOI : 10.2337/db09-1478
PMID : 20682686

ISSN of the journal0012-1797

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INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells

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