UNIGE document Scientific Article
previous document  unige:33550  next document
add to browser collection
Title

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells
Authors
Bonner, Caroline
Bacon, Siobhán
Concannon, Caoimhín G
Rizvi, Syed R
Baquie, Mathurin
Farrelly, Angela M
Kilbride, Seán M
Dussmann, Heiko
show hidden authors show all authors [1 - 14]
Published in Diabetes. 2010, vol. 59, no. 11, p. 2799-808
Abstract In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased β-cell mass and HNF1A-maturity onset diabetes of the young (HNF1A-MODY). Here, we investigated the effect of a dominant-negative HNF1A mutant (DN-HNF1A) induced apoptosis on the regenerative capacity of INS-1 cells.
Keywords Animals — Apoptosis — Caspase 3/metabolism — Caspases/genetics/pharmacology — Cell Death/drug effects — Diabetes Mellitus, Type 2/genetics/physiopathology — Enzyme-Linked Immunosorbent Assay — Hepatocyte Nuclear Factor 1-alpha/genetics/pharmacology — Humans — Insulin-Secreting Cells/cytology/drug effects/physiology — Insulinoma/genetics — Mice — Mice, Inbred C57BL — Mice, Transgenic — Promoter Regions, Genetic — Rats — Reverse Transcriptase Polymerase Chain Reaction
Identifiers
PMID: 20682686
Full text
Article (Published version) (289 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Citation
(ISO format) 		BONNER, Caroline et al. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. In: Diabetes, 2010, vol. 59, n° 11, p. 2799-808. doi: 10.2337/db09-1478 https://archive-ouverte.unige.ch/unige:33550

418 hits

265 downloads

Contact an author

Update request

Update

Deposited on : 2014-01-22

Export document
Format :
Citation style :