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INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells |
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Published in | Diabetes. 2010, vol. 59, no. 11, p. 2799-808 | |
Abstract | In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased β-cell mass and HNF1A-maturity onset diabetes of the young (HNF1A-MODY). Here, we investigated the effect of a dominant-negative HNF1A mutant (DN-HNF1A) induced apoptosis on the regenerative capacity of INS-1 cells. | |
Keywords | Animals — Apoptosis — Caspase 3/metabolism — Caspases/genetics/pharmacology — Cell Death/drug effects — Diabetes Mellitus, Type 2/genetics/physiopathology — Enzyme-Linked Immunosorbent Assay — Hepatocyte Nuclear Factor 1-alpha/genetics/pharmacology — Humans — Insulin-Secreting Cells/cytology/drug effects/physiology — Insulinoma/genetics — Mice — Mice, Inbred C57BL — Mice, Transgenic — Promoter Regions, Genetic — Rats — Reverse Transcriptase Polymerase Chain Reaction | |
Identifiers | DOI: 10.2337/db09-1478 PMID: 20682686 | |
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Citation (ISO format) | BONNER, Caroline et al. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. In: Diabetes, 2010, vol. 59, n° 11, p. 2799-808. doi: 10.2337/db09-1478 https://archive-ouverte.unige.ch/unige:33550 |