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Scientific article
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Mitochondrial function and insulin secretion

ContributorsMaechler, Pierreorcid
Published inMolecular and cellular endocrinology, vol. 379, no. 1-2, p. 12-18
Publication date2013
Abstract

In the endocrine fraction of the pancreas, the β-cell rapidly reacts to fluctuations in blood glucose concentrations by adjusting the rate of insulin secretion. Glucose-sensing coupled to insulin exocytosis depends on transduction of metabolic signals into intracellular messengers recognized by the secretory machinery. Mitochondria play a central role in this process by connecting glucose metabolism to insulin release. Mitochondrial activity is primarily regulated by metabolic fluxes, but also by dynamic morphology changes and free Ca(2+) concentrations. Recent advances of mitochondrial Ca(2+) homeostasis are discussed; in particular the roles of the newly-identified mitochondrial Ca(2+) uniporter MCU and its regulatory partner MICU1, as well as the mitochondrial Na(+)-Ca(2+) exchanger. This review describes how mitochondria function both as sensors and generators of metabolic signals; such as NADPH, long chain acyl-CoA, glutamate. The coupling factors are additive to the Ca(2+) signal and participate to the amplifying pathway of glucose-stimulated insulin secretion.

Citation (ISO format)
MAECHLER, Pierre. Mitochondrial function and insulin secretion. In: Molecular and cellular endocrinology, 2013, vol. 379, n° 1-2, p. 12–18. doi: 10.1016/j.mce.2013.06.019
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ISSN of the journal0303-7207
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