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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

Marchetti, P
Lupi, R
Sebastiani, G
Grieco, F A
Del Guerra, S
D'Aleo, V
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Published in Diabetologia. 2012, vol. 55, no. 12, p. 3262-72
Abstract Glucagon-like peptide 1 (GLP-1) is a major incretin, mainly produced by the intestinal L cells, with beneficial actions on pancreatic beta cells. However, while in vivo only very small amounts of GLP-1 reach the pancreas in bioactive form, some observations indicate that GLP-1 may also be produced in the islets. We performed comprehensive morphological, functional and molecular studies to evaluate the presence and various features of a local GLP-1 system in human pancreatic islet cells, including those from type 2 diabetic patients.
Keywords Diabetes Mellitus, Type 2/metabolismFemaleGlucagon/metabolismGlucagon-Like Peptide 1/metabolismGlucagon-Secreting Cells/metabolismHumansImmunohistochemistryInsulin/metabolismMaleMass SpectrometryMiddle AgedPancreas/metabolism
PMID: 22965295
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MARCHETTI, P et al. A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. In: Diabetologia, 2012, vol. 55, n° 12, p. 3262-72. doi: 10.1007/s00125-012-2716-9 https://archive-ouverte.unige.ch/unige:33353

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Deposited on : 2014-01-16

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