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Carriage of extended-spectrum beta-lactamase-producing enterobacteriacae among internal medicine patients in Switzerland

Pasricha, Janet
Koessler, Thibaud
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Published in Antimicrobial resistance and infection control. 2013, vol. 2, no. 1, 20
Abstract BACKGROUND: The incidence of extended-spectrum beta-lactamase producing-enterobacteriacae (ESBL-E) infection is rising worldwide. We aimed to determine the prevalence and nosocomial acquisition rate of ESBL-E as well as the risk factors for ESBL-E carriage and acquisition amongst patients consecutively admitted to 13 internal medicine units at our hospital who were not previously known to be ESBL-E carriers. FINDINGS: We screened all patients admitted or transferred to internal medicine units for ESBL-E on admission and discharge using rectal swabs. Of 1072 patients screened, 51 (4.8%) were carriers of an ESBL-E at admission. Of 473 patients who underwent admission and discharge screening, 21 (4.4%) acquired an ESBL-E. On multivariate analysis, diabetes mellitus without end-organ complications (OR 2.8 [1.1-7.1]), connective tissue disease (OR 7.2 [1.2-44.6], and liver failure (OR 8.4 [1.5-45.4]) were independent risk factors for carriage of an ESBL-E upon admission to hospital (area under the ROC curve, 0.68). Receipt of a first- or second-generation cephalosporin (OR 9.25 [2.2-37.8]), intra-hospital transfer (OR 6.7 [1.7-26.1]), and a hospital stay >21 days (OR 25.1 [4.2-151.7]) were associated with acquisition of an ESBL-E during hospitalisation; whilst admission from home was protective (OR 0.16 [0.06-0.39]) on univariate regression. No risk profile with sufficient accuracy to predict previously unknown carriage on admission or acquisition of ESBL-E could be developed using readily available patient information. CONCLUSIONS: ESBL-E carriage is endemic amongst internal medicine patients at our institution. We were unable to develop a clinical risk profile to accurately predict ESBL-E carriage amongst these patients.
PMID: 23759067
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Research groups Analyse génomique et fonctionnelle du staphylocoque doré (604)
Epidémiologie et contrôle de la résistance aux antibiotiques (866)
Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
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PASRICHA, Janet et al. Carriage of extended-spectrum beta-lactamase-producing enterobacteriacae among internal medicine patients in Switzerland. In: Antimicrobial resistance and infection control, 2013, vol. 2, n° 1, p. 20. doi: 10.1186/2047-2994-2-20 https://archive-ouverte.unige.ch/unige:33309

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Deposited on : 2014-01-16

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