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Title

Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress

Authors
Zotti, Margherita
Tucci, Paolo
Morgese, Maria Grazia
Bäckdahl, Liselotte
Holmdahl, Rikard
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Published in Antioxidants and Redox Signaling. 2013, vol. 18, no. 12, p. 1385-99
Abstract Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major source of reactive oxygen species (ROS) in the central nervous system. Here, we investigated the contributory role of NOX2-derived ROS to the development of neuroendocrine alterations in a rat model of chronic psychosocial stress, the social isolation.
Keywords Acetophenones/pharmacologyAdrenal Glands/metabolismAdrenocorticotropic Hormone/bloodAnimalsAntioxidants/pharmacologyBiological Markers/bloodCorticosterone/bloodDeoxyguanosine/analogs & derivatives/metabolismFemaleHypothalamo-Hypophyseal System/metabolismHypothalamus/metabolismMaleMutationNADPH Oxidase/genetics/metabolismNeurosecretory Systems/metabolismOxidative StressPituitary-Adrenal System/metabolismPsychosocial DeprivationPsychotic Disorders/metabolismRatsRats, WistarRestraint, PhysicalSaliva/metabolismSocial IsolationStress, Psychological/bloodTyrosine/analogs & derivatives/metabolism
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PMID: 23320850
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Structures
Research group Radicaux libres et cellules souches embryonnaires (60)
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COLAIANNA, Marilena et al. Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. In: Antioxidants and Redox Signaling, 2013, vol. 18, n° 12, p. 1385-99. https://archive-ouverte.unige.ch/unige:32473

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Deposited on : 2013-12-18

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