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Scientific article
English

Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress

Published inAntioxidants & redox signaling, vol. 18, no. 12, p. 1385-1399
Publication date2013
Abstract

Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major source of reactive oxygen species (ROS) in the central nervous system. Here, we investigated the contributory role of NOX2-derived ROS to the development of neuroendocrine alterations in a rat model of chronic psychosocial stress, the social isolation.

Keywords
  • Acetophenones/pharmacology
  • Adrenal Glands/metabolism
  • Adrenocorticotropic Hormone/blood
  • Animals
  • Antioxidants/pharmacology
  • Biological Markers/blood
  • Corticosterone/blood
  • Deoxyguanosine/analogs & derivatives/metabolism
  • Female
  • Hypothalamo-Hypophyseal System/metabolism
  • Hypothalamus/metabolism
  • Male
  • Mutation
  • NADPH Oxidase/genetics/metabolism
  • Neurosecretory Systems/metabolism
  • Oxidative Stress
  • Pituitary-Adrenal System/metabolism
  • Psychosocial Deprivation
  • Psychotic Disorders/metabolism
  • Rats
  • Rats, Wistar
  • Restraint, Physical
  • Saliva/metabolism
  • Social Isolation
  • Stress, Psychological/blood
  • Tyrosine/analogs & derivatives/metabolism
Citation (ISO format)
COLAIANNA, Marilena et al. Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. In: Antioxidants & redox signaling, 2013, vol. 18, n° 12, p. 1385–1399. doi: 10.1089/ars.2012.4569
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1523-0864
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Creation11/19/2013 5:05:00 PM
First validation11/19/2013 5:05:00 PM
Update time03/15/2023 2:12:17 PM
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