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Title

Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules
Authors
Olleros, Maria-Luisa
Vesin, Marie-Dominique
Bisig, Ruth
Santiago-Raber, Marie-Laure
Schuepbach-Mallepell, Sonia
Kollias, George
Gaide, Olivier
Garcia, Irène
Published in PloS one. 2012, vol. 7, no. 5, e31469
Abstract Several activities of the transmembrane form of TNF (memTNF) in immune responses to intracellular bacterial infection have been shown to be different from those exerted by soluble TNF. Evidence is based largely on studies in transgenic mice expressing memTNF, but precise cellular mechanisms are not well defined and the importance of TNF receptor regulation is unknown. In addition, memTNF activities are defined for a particular modification of the extracellular domain of TNF but a direct comparison of different mutant memTNF molecules has not been done in vivo.
Keywords Animals — Bone Marrow Cells/cytology — Cell Membrane/metabolism — Chemokines/metabolism — Disease Resistance/immunology — Gene Knock-In Techniques — Interferon-gamma/immunology/metabolism — Intracellular Space/immunology/metabolism/microbiology — Macrophages/immunology/metabolism/microbiology — Mice — Mice, Inbred C57BL — Mycobacterium bovis/immunology/pathogenicity — NF-kappa B/metabolism — Nitric Oxide/metabolism — Nitric Oxide Synthase Type II/metabolism — Receptors, Tumor Necrosis Factor, Type II/chemistry/metabolism — Solubility — Tuberculosis/immunology/veterinary — Tumor Necrosis Factor-alpha/genetics/metabolism
Identifiers
PMID: 22666310
Full text
Article (Published version) (1.7 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)
Projects
Swiss National Science Foundation: 3200A0-118196
Autre: Science and Technology Cooperation Program Switzerland-Russia
Citation
(ISO format) 		OLLEROS, Maria-Luisa et al. Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules. In: PloS one, 2012, vol. 7, n° 5, p. e31469. doi: 10.1371/journal.pone.0031469 https://archive-ouverte.unige.ch/unige:32287

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Deposited on : 2013-12-17

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