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Title

Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules

Authors
Schuepbach-Mallepell, Sonia
Kollias, George
Published in PLOS ONE. 2012, vol. 7, no. 5, p. e31469
Abstract Several activities of the transmembrane form of TNF (memTNF) in immune responses to intracellular bacterial infection have been shown to be different from those exerted by soluble TNF. Evidence is based largely on studies in transgenic mice expressing memTNF, but precise cellular mechanisms are not well defined and the importance of TNF receptor regulation is unknown. In addition, memTNF activities are defined for a particular modification of the extracellular domain of TNF but a direct comparison of different mutant memTNF molecules has not been done in vivo.
Keywords AnimalsBone Marrow Cells/cytologyCell Membrane/metabolismChemokines/metabolismDisease Resistance/immunologyGene Knock-In TechniquesInterferon-gamma/immunology/metabolismIntracellular Space/immunology/metabolism/microbiologyMacrophages/immunology/metabolism/microbiologyMiceMice, Inbred C57BLMycobacterium bovis/immunology/pathogenicityNF-kappa B/metabolismNitric Oxide/metabolismNitric Oxide Synthase Type II/metabolismReceptors, Tumor Necrosis Factor, Type II/chemistry/metabolismSolubilityTuberculosis/immunology/veterinaryTumor Necrosis Factor-alpha/genetics/metabolism
Identifiers
PMID: 22666310
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Article (Published version) (1.7 MB) - public document Free access
Structures
Research group Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)
Projects FNS: 3200A0-118196
Science and Technology Cooperation Program Switzerland-Russia
Citation
(ISO format)
OLLEROS, Maria-Luisa et al. Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules. In: PLOS ONE, 2012, vol. 7, n° 5, p. e31469. https://archive-ouverte.unige.ch/unige:32287

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Deposited on : 2013-12-17

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