en
Scientific article
Open access
English

Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules

Published inPloS one, vol. 7, no. 5, e31469
Publication date2012
Abstract

Several activities of the transmembrane form of TNF (memTNF) in immune responses to intracellular bacterial infection have been shown to be different from those exerted by soluble TNF. Evidence is based largely on studies in transgenic mice expressing memTNF, but precise cellular mechanisms are not well defined and the importance of TNF receptor regulation is unknown. In addition, memTNF activities are defined for a particular modification of the extracellular domain of TNF but a direct comparison of different mutant memTNF molecules has not been done in vivo.

Keywords
  • Animals
  • Bone Marrow Cells/cytology
  • Cell Membrane/metabolism
  • Chemokines/metabolism
  • Disease Resistance/immunology
  • Gene Knock-In Techniques
  • Interferon-gamma/immunology/metabolism
  • Intracellular Space/immunology/metabolism/microbiology
  • Macrophages/immunology/metabolism/microbiology
  • Mice
  • Mice, Inbred C57BL
  • Mycobacterium bovis/immunology/pathogenicity
  • NF-kappa B/metabolism
  • Nitric Oxide/metabolism
  • Nitric Oxide Synthase Type II/metabolism
  • Receptors, Tumor Necrosis Factor, Type II/chemistry/metabolism
  • Solubility
  • Tuberculosis/immunology/veterinary
  • Tumor Necrosis Factor-alpha/genetics/metabolism
Funding
  • Swiss National Science Foundation - 3200A0-118196
  • Autre - Science and Technology Cooperation Program Switzerland-Russia
Citation (ISO format)
OLLEROS, Maria-Luisa et al. Membrane-bound TNF induces protective immune responses to M. bovis BCG infection: regulation of memTNF and TNF receptors comparing two memTNF molecules. In: PloS one, 2012, vol. 7, n° 5, p. e31469. doi: 10.1371/journal.pone.0031469
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
628views
590downloads

Technical informations

Creation11/07/2013 4:21:00 PM
First validation11/07/2013 4:21:00 PM
Update time03/14/2023 8:44:20 PM
Status update03/14/2023 8:44:20 PM
Last indexation02/12/2024 11:18:13 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack