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From expression QTLs to personalized transcriptomics

Published in Nature Reviews Genetics. 2011, vol. 12, no. 4, p. 277-82
Abstract Approaches that combine expression quantitative trait loci (eQTLs) and genome-wide association (GWA) studies are offering new functional information about the aetiology of complex human traits and diseases. Improved study designs--which take into account technological advances in resolving the transcriptome, cell history and state, population of origin and diverse endophenotypes--are providing insights into the architecture of disease and the landscape of gene regulation in humans. Furthermore, these advances are helping to establish links between cellular effects and organismal traits.
Keywords EndophenotypesGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyHumansQuantitative Trait Loci/genetics
PMID: 21386863
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Research group Population Genomics and Genetics of Complex Traits (892)
Project Jeantet
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MONTGOMERY, Stephen, DERMITZAKIS, Emmanouil. From expression QTLs to personalized transcriptomics. In: Nature Reviews Genetics, 2011, vol. 12, n° 4, p. 277-82. doi: 10.1038/nrg2969 https://archive-ouverte.unige.ch/unige:32208

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Deposited on : 2013-12-16

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