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Title

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Author
Strawbridge, Rona J
CollaborationWith : Nica, Alexandra / Ongen, Halit / Dermitzakis, Emmanouil
Published in Diabetes. 2011, vol. 60, no. 10, p. 2624-34
Abstract Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.
Keywords Adult — Diabetes Mellitus, Type 2/blood/genetics/metabolism — Fasting/blood — Female — Genetic Variation — Genome, Human — Genotype — Humans — Insulin/blood — Male — Polymorphism, Single Nucleotide/genetics — Proinsulin/blood
Identifiers
PMID: 21873549
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Article (Published version) (965 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research group Population Genomics and Genetics of Complex Traits (892)
Project Jeantet
Citation
(ISO format) 		STRAWBRIDGE, Rona J. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. In: Diabetes, 2011, vol. 60, n° 10, p. 2624-34. doi: 10.2337/db11-0415 https://archive-ouverte.unige.ch/unige:32202

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Deposited on : 2013-12-16

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