Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge, Rona J; Dupuis, Josée; Prokopenko, Inga; Barker, Adam; Ahlqvist, Emma; Rybin, Denis; Petrie, John R; Travers, Mary E; Bouatia-Naji, Nabila; Dimas, Antigone a; Nica, Alexandra; Wheeler, Eleanor; Chen, Han; Voight, Benjamin F; Taneera, Jalal; Kanoni, Stavroula; Peden, John F; Turrini, Fabiola; Gustafsson, Stefan; Zabena, Carina; Almgren, Peter; Barker, David J P; Barnes, Daniel; Dennison, Elaine M; Eriksson, Johan G; Eriksson, Per; Eury, Elodie; Folkersen, Lasse; Fox, Caroline S; Frayling, Timothy M; Goel, Anuj; Gu, Harvest F; Horikoshi, Momoko; Isomaa, Bo; Jackson, Anne U; Jameson, Karen A; Kajantie, Eero; Kerr-Conte, Julie; Kuulasmaa, Teemu; Kuusisto, Johanna; Loos, Ruth J F; Luan, Jian'an; Makrilakis, Konstantinos; Manning, Alisa K; Martínez-Larrad, María Teresa; Narisu, Narisu; Nastase Mannila, Maria; Ohrvik, John; Osmond, Clive; Pascoe, Laura; Payne, Felicity; Sayer, Avan A; Sennblad, Bengt; Silveira, Angela; Stancáková, Alena; Stirrups, Kathy; Swift, Amy J; Syvänen, Ann-Christine; Tuomi, Tiinamaija; van 't Hooft, Ferdinand M; Walker, Mark; Weedon, Michael N; Xie, Weijia; Zethelius, Björn; Ongen, Halit; Mälarstig, Anders; Hopewell, Jemma C; Saleheen, Danish; Chambers, John; Parish, Sarah; Danesh, John; Kooner, Jaspal; Ostenson, Claes-Göran; Lind, Lars; Cooper, Cyrus C; Serrano-Ríos, Manuel; Ferrannini, Ele; Forsen, Tom J; Clarke, Robert; Franzosi, Maria Grazia; Seedorf, Udo; Watkins, Hugh; Froguel, Philippe; Johnson, Paul; Deloukas, Panos; Collins, Francis S; Laakso, Markku; Dermitzakis, Emmanouil; Boehnke, Michael; McCarthy, Mark I; Wareham, Nicholas J; Groop, Leif; Pattou, François; Gloyn, Anna L; Dedoussis, George V; Lyssenko, Valeriya; Meigs, James B; Barroso, Inês

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Title		Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Authors		Strawbridge, Rona J Dupuis, Josée Prokopenko, Inga Barker, Adam Ahlqvist, Emma Rybin, Denis Petrie, John R Travers, Mary E Bouatia-Naji, Nabila Dimas, Antigone a Nica, Alexandra Wheeler, Eleanor Chen, Han Voight, Benjamin F Taneera, Jalal Kanoni, Stavroula Peden, John F Turrini, Fabiola Gustafsson, Stefan Zabena, Carina Almgren, Peter Barker, David J P Barnes, Daniel Dennison, Elaine M Eriksson, Johan G Eriksson, Per Eury, Elodie Folkersen, Lasse Fox, Caroline S Frayling, Timothy M Goel, Anuj Gu, Harvest F Horikoshi, Momoko Isomaa, Bo Jackson, Anne U Jameson, Karen A Kajantie, Eero Kerr-Conte, Julie Kuulasmaa, Teemu Kuusisto, Johanna Loos, Ruth J F Luan, Jian'an Makrilakis, Konstantinos Manning, Alisa K Martínez-Larrad, María Teresa Narisu, Narisu Nastase Mannila, Maria Ohrvik, John Osmond, Clive Pascoe, Laura Payne, Felicity Sayer, Avan A Sennblad, Bengt Silveira, Angela Stancáková, Alena Stirrups, Kathy Swift, Amy J Syvänen, Ann-Christine Tuomi, Tiinamaija van 't Hooft, Ferdinand M Walker, Mark Weedon, Michael N Xie, Weijia Zethelius, Björn Ongen, Halit Mälarstig, Anders Hopewell, Jemma C Saleheen, Danish Chambers, John Parish, Sarah Danesh, John Kooner, Jaspal Ostenson, Claes-Göran Lind, Lars Cooper, Cyrus C Serrano-Ríos, Manuel Ferrannini, Ele Forsen, Tom J Clarke, Robert Franzosi, Maria Grazia Seedorf, Udo Watkins, Hugh Froguel, Philippe Johnson, Paul Deloukas, Panos Collins, Francis S Laakso, Markku Dermitzakis, Emmanouil Boehnke, Michael McCarthy, Mark I Wareham, Nicholas J Groop, Leif Pattou, François Gloyn, Anna L Dedoussis, George V Lyssenko, Valeriya Meigs, James B Barroso, Inês show all authors [1 - 98]
Published in		Diabetes. 2011, vol. 60, no. 10, p. 2624-34
Abstract		Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.
Keywords		Adult — Diabetes Mellitus, Type 2/blood/genetics/metabolism — Fasting/blood — Female — Genetic Variation — Genome, Human — Genotype — Humans — Insulin/blood — Male — Polymorphism, Single Nucleotide/genetics — Proinsulin/blood
Identifiers		DOI: 10.2337/db11-0415 PMID: 21873549
Full text		Article (Published version) (965 Kb) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research group		Population Genomics and Genetics of Complex Traits (892)
Project		Jeantet
Citation (ISO format)		STRAWBRIDGE, Rona J et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. In: Diabetes, 2011, vol. 60, n° 10, p. 2624-34. https://archive-ouverte.unige.ch/unige:32202