Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge, Rona J

doi:10.2337/db11-0415

Scientific article

Open access

English

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

ContributorsStrawbridge, Rona J

CollaboratorsNica, Alexandra; Ongen, Halit; Dermitzakis, Emmanouil

Published inDiabetes, vol. 60, no. 10, p. 2624-2634

Publication date2011

Abstract

Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.

Keywords

Adult
Diabetes Mellitus, Type 2/blood/genetics/metabolism
Fasting/blood
Female
Genetic Variation
Genome, Human
Genotype
Humans
Insulin/blood
Male
Polymorphism, Single Nucleotide/genetics
Proinsulin/blood

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Research group

Population Genomics and Genetics of Complex Traits (892)

Funding

Autre - Jeantet

Citation (ISO format)

STRAWBRIDGE, Rona J. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. In: Diabetes, 2011, vol. 60, n° 10, p. 2624–2634. doi: 10.2337/db11-0415

Article (Published version)

Identifiers

PID : unige:32202
DOI : 10.2337/db11-0415
PMID : 21873549

ISSN of the journal0012-1797

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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

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