en
Scientific article
Open access
English

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Published inDiabetes, vol. 60, no. 10, p. 2624-2634
Publication date2011
Abstract

Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.

Keywords
  • Adult
  • Diabetes Mellitus, Type 2/blood/genetics/metabolism
  • Fasting/blood
  • Female
  • Genetic Variation
  • Genome, Human
  • Genotype
  • Humans
  • Insulin/blood
  • Male
  • Polymorphism, Single Nucleotide/genetics
  • Proinsulin/blood
Funding
  • Autre - Jeantet
Citation (ISO format)
STRAWBRIDGE, Rona J. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. In: Diabetes, 2011, vol. 60, n° 10, p. 2624–2634. doi: 10.2337/db11-0415
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0012-1797
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1438downloads

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First validation12/15/2013 11:12:00 PM
Update time03/14/2023 8:43:40 PM
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