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Title

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Authors
Strawbridge, Rona J
Dupuis, Josée
Prokopenko, Inga
Barker, Adam
Ahlqvist, Emma
Rybin, Denis
Petrie, John R
Travers, Mary E
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Published in Diabetes. 2011, vol. 60, no. 10, p. 2624-34
Abstract Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.
Keywords AdultDiabetes Mellitus, Type 2/blood/genetics/metabolismFasting/bloodFemaleGenetic VariationGenome, HumanGenotypeHumansInsulin/bloodMalePolymorphism, Single Nucleotide/geneticsProinsulin/blood
Identifiers
PMID: 21873549
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Article (Published version) (965 Kb) - public document Free access
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Research group Population Genomics and Genetics of Complex Traits (892)
Project Jeantet
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STRAWBRIDGE, Rona J et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. In: Diabetes, 2011, vol. 60, n° 10, p. 2624-34. https://archive-ouverte.unige.ch/unige:32202

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Deposited on : 2013-12-16

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