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Cellular genomics for complex traits

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Published in Nature Reviews Genetics. 2012, vol. 13, no. 3, p. 215-20
Abstract Recent developments in the collection and analysis of cellular multilayered data in large cohorts with extensive organismal phenotyping promise to reveal links between genetic variation and biological processes. The use of these cellular resources as models for human biology - known as 'cellular phenotyping' - is likely to transform our understanding of the genetic and long-term environmental influences on complex traits. I discuss the advantages and caveats of a deeper analysis of cellular phenotypes in large cohorts and assess the methodological advances, resource needs and prospects of this new approach.
Keywords Genetic VariationGenomicsHumansPhenotypeQuantitative Trait, Heritable
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PMID: 22330769
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Article (Published version) (387 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Population Genomics and Genetics of Complex Traits (892)
Project Jeantet
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DERMITZAKIS, Emmanouil. Cellular genomics for complex traits. In: Nature Reviews Genetics, 2012, vol. 13, n° 3, p. 215-20. https://archive-ouverte.unige.ch/unige:32196

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Deposited on : 2013-12-16

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