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Title

Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals

Authors
Lubomirov, Rubin
Rotger, Margalida
Fayet-Mello, Aurélie
Martinez, Raquel
di Iulio, Julia
Cavassini, Matthias
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Published in Pharmacogenetics and genomics. 2013, vol. 23, no. 1, p. 9-18
Abstract Etravirine (ETV) is metabolized by cytochrome P450 (CYP) 3A, 2C9, and 2C19. Metabolites are glucuronidated by uridine diphosphate glucuronosyltransferases (UGT). To identify the potential impact of genetic and non-genetic factors involved in ETV metabolism, we carried out a two-step pharmacogenetics-based population pharmacokinetic study in HIV-1 infected individuals.
Keywords AdolescentAdultAgedAryl Hydrocarbon Hydroxylases/geneticsCytochrome P-450 CYP3A/geneticsFemaleHIV Infections/drug therapy/epidemiology/geneticsHIV Protease Inhibitors/pharmacokinetics/pharmacologyHIV-1/drug effects/geneticsHumansMaleMiddle AgedModelsStatisticalPharmacogeneticsPolymorphismSingle Nucleotide/geneticsPrognosisProspective StudiesPyridazines/pharmacokinetics/pharmacologySwitzerland/epidemiologyTissue DistributionYoung Adult
Identifiers
PMID: 23111422
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Article (Published version) (595 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group VIH/SIDA (930)
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LUBOMIROV, Rubin et al. Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals. In: Pharmacogenetics and genomics, 2013, vol. 23, n° 1, p. 9-18. doi: 10.1097/FPC.0b013e32835ade82 https://archive-ouverte.unige.ch/unige:32157

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Deposited on : 2013-12-16

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