Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals

Article Article scientifique Article Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals eng 2013 author Lubomirov Rubin author Arab Mona 631977 author Rotger Margalida author Fayet-Mello Aurélie author Martinez Raquel author Guidi Monia 762075 author di Iulio Julia author Cavassini Matthias author Günthard Huldrych F author Furrer Hansjakob author Marzolini Catia author Bernasconi Enos 663410 author Calmy Alexandra 0000-0002-1137-6826 41032 author Buclin Thierry 648525 author Decosterd Laurent 826211 author Csajka Chantal 657943 author Telenti Amalio 9-18 10.1097/FPC.0b013e32835ade82 23111422 1744-6872 Etravirine (ETV) is metabolized by cytochrome P450 (CYP) 3A, 2C9, and 2C19. Metabolites are glucuronidated by uridine diphosphate glucuronosyltransferases (UGT). To identify the potential impact of genetic and non-genetic factors involved in ETV metabolism, we carried out a two-step pharmacogenetics-based population pharmacokinetic study in HIV-1 infected individuals. Adolescent Adult Aged Aryl Hydrocarbon Hydroxylases/genetics Cytochrome P-450 CYP3A/genetics Female HIV Infections/drug therapy/epidemiology/genetics HIV Protease Inhibitors/pharmacokinetics/pharmacology HIV-1/drug effects/genetics Humans Male Middle Aged Models Statistical Pharmacogenetics Polymorphism Single Nucleotide/genetics Prognosis Prospective Studies Pyridazines/pharmacokinetics/pharmacology Switzerland/epidemiology Tissue Distribution Young Adult Dewey 615 Dewey 616 31 Section des sciences pharmaceutiques 17 56 Département de médecine 221 false 587 VIH/SIDA 930 Pharmacogenetics and genomics 23 1 4a7f4e7f-0e4f-4aa5-8a1c-93f72e080676 Article (Published version) Restricted PharmacoPopul_PharmacoGeno.pdf 609605 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Year	Views	Downloads

Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals	Pharmacogenetics and genomics	2013	658	0
Population pharmacokinetics and pharmacogenetics of antiretroviral drugs		2012	909	1,645

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