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The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice

ContributorsZhang, Ye; Xie, Zhifang; Zhou, Luting; Li, Ling; Zhang, Hai; Zhou, Guangdi; Ma, Xianhua; Herrera, Pedro Luisorcid; Liu, Zhimin; Grusby, Michael J; Zhang, Weiping J
Published inGastroenterology, vol. 142, no. 7, p. 1571-1580.e6
Publication date2012
Abstract

Fructose-1,6-bisphosphatase (FBP)-1 is a gluconeogenic enzyme that regulates glucose metabolism and insulin secretion in β cells, but little is known about how its transcription is controlled. The zinc finger protein ZBTB20 regulates glucose homeostasis, so we investigated its effects on expression of FBP-1.

Keywords
  • Animals
  • Cell Line
  • Fructose-Bisphosphatase/genetics/metabolism
  • Gene Expression
  • Gene Knockdown Techniques
  • Glucose/metabolism
  • Glucose Intolerance/metabolism
  • Hepatocytes/metabolism
  • Insulin/secretion
  • Insulin-Secreting Cells/metabolism
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Repressor Proteins/metabolism/physiology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription, Genetic
  • Zinc Fingers
Affiliation entities
Research groups
Citation (ISO format)
ZHANG, Ye et al. The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice. In: Gastroenterology, 2012, vol. 142, n° 7, p. 1571–1580.e6. doi: 10.1053/j.gastro.2012.02.043
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Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0016-5085
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751downloads

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