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Title

The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice

Authors
Zhang, Ye
Xie, Zhifang
Zhou, Luting
Li, Ling
Zhang, Hai
Zhou, Guangdi
Ma, Xianhua
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Published in Gastroenterology. 2012, vol. 142, no. 7, p. 1571-1580.e6
Abstract Fructose-1,6-bisphosphatase (FBP)-1 is a gluconeogenic enzyme that regulates glucose metabolism and insulin secretion in β cells, but little is known about how its transcription is controlled. The zinc finger protein ZBTB20 regulates glucose homeostasis, so we investigated its effects on expression of FBP-1.
Keywords AnimalsCell LineFructose-Bisphosphatase/genetics/metabolismGene ExpressionGene Knockdown TechniquesGlucose/metabolismGlucose Intolerance/metabolismHepatocytes/metabolismInsulin/secretionInsulin-Secreting Cells/metabolismMiceMice, KnockoutMice, TransgenicRepressor Proteins/metabolism/physiologyReverse Transcriptase Polymerase Chain ReactionTranscription, GeneticZinc Fingers
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PMID: 22374165
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Article (Published version) (4.2 MB) - public document Free access
Structures
Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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ZHANG, Ye et al. The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice. In: Gastroenterology, 2012, vol. 142, n° 7, p. 1571-1580.e6. https://archive-ouverte.unige.ch/unige:32136

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Deposited on : 2013-12-16

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