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Title

An active product of cruciferous vegetables, 3,3'-diindolylmethane, inhibits invasive properties of extravillous cytotrophoblastic cells

Authors
Ribaux, Pascale
Published in Neuroendocrinology Letters. 2012, vol. 33, no. 2, p. 133-7
Abstract During implantation, human trophoblastic cells have to proliferate, migrate and invade pregnant uterus. A natural product of cruciferous vegetables, 3,3'-diindolylmethane (DIM), is known to induce some stress response genes (such as glucose-regulated protein 78 kDa (GRP78)) and to have anti-invasive and pro-apoptotic effects on tumor cells. Therefore, we have investigated the potential effect of DIM on invasive extravillous cytotrophoblasts (evCTBs) cells.
Keywords Anticarcinogenic Agents/pharmacologyCell Movement/drug effectsCells, CulturedFemaleGene Expression/drug effectsHeat-Shock Proteins/biosynthesisHumansIndoles/pharmacologyMatrix Metalloproteinases/biosynthesisPregnancyTrophoblasts/drug effects/metabolism
Identifiers
PMID: 22592193
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Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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RIBAUX, Pascale, IRION, Olivier, COHEN, Marie-Benoîte. An active product of cruciferous vegetables, 3,3'-diindolylmethane, inhibits invasive properties of extravillous cytotrophoblastic cells. In: Neuroendocrinology Letters, 2012, vol. 33, n° 2, p. 133-7. https://archive-ouverte.unige.ch/unige:31958

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Deposited on : 2013-12-10

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