Scientific article

An active product of cruciferous vegetables, 3,3'-diindolylmethane, inhibits invasive properties of extravillous cytotrophoblastic cells

Published inNeuro-endocrinology letters, vol. 33, no. 2, p. 133-137
Publication date2012

During implantation, human trophoblastic cells have to proliferate, migrate and invade pregnant uterus. A natural product of cruciferous vegetables, 3,3'-diindolylmethane (DIM), is known to induce some stress response genes (such as glucose-regulated protein 78 kDa (GRP78)) and to have anti-invasive and pro-apoptotic effects on tumor cells. Therefore, we have investigated the potential effect of DIM on invasive extravillous cytotrophoblasts (evCTBs) cells.

  • Anticarcinogenic Agents/pharmacology
  • Cell Movement/drug effects
  • Cells, Cultured
  • Female
  • Gene Expression/drug effects
  • Heat-Shock Proteins/biosynthesis
  • Humans
  • Indoles/pharmacology
  • Matrix Metalloproteinases/biosynthesis
  • Pregnancy
  • Trophoblasts/drug effects/metabolism
Citation (ISO format)
RIBAUX, Pascale, IRION, Olivier, COHEN, Marie-Benoîte. An active product of cruciferous vegetables, 3,3′-diindolylmethane, inhibits invasive properties of extravillous cytotrophoblastic cells. In: Neuro-endocrinology letters, 2012, vol. 33, n° 2, p. 133–137.
ISSN of the journal0172-780X

Technical informations

Creation10/28/2013 3:41:00 PM
First validation10/28/2013 3:41:00 PM
Update time03/14/2023 8:42:03 PM
Status update03/14/2023 8:42:03 PM
Last indexation01/16/2024 8:27:07 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack