Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas

Cohen, Marie-Benoîte; Ribaux, Pascale Garlonne; Epiney, Emmanuela; Irion, Olivier

Scientific article

English

Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas

ContributorsCohen, Marie-Benoîte

; Ribaux, Pascale Garlonne; Epiney, Emmanuela; Irion, Olivier

Published inNeuro-endocrinology letters, vol. 33, no. 4, p. 406-411

Publication date2012

Abstract

Preeclampsia is a specific pregnancy disorder which could be due, at least in part, to impaired invasion of trophoblastic cells. Since matrix metalloproteinases (MMPs) are the predominant proteases involved in trophoblastic invasion, we investigated and compared expression of MMP-1, 2, 7, 9 and 12 of cytotrophoblastic cells (CTB) purified from preeclamptic (PE) placentas to control CTB.

Keywords

Cells, Cultured
Female
Humans
Metalloproteases/classification/genetics/metabolism
Placenta/enzymology
Pre-Eclampsia/enzymology/physiopathology
Pregnancy
Pregnancy Trimester, Third/metabolism
RNA, Messenger/analysis
Trophoblasts/enzymology

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

Laboratoire de biologie des tumeurs gynécologiques et du développement (927)

Citation (ISO format)

COHEN, Marie-Benoîte et al. Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas. In: Neuro-endocrinology letters, 2012, vol. 33, n° 4, p. 406–411.

Article (Published version)

Identifiers

PID : unige:31949
PMID : 22936257

Commercial URLhttp://www.nel.edu/expression-of-metalloproteinases-1-2-7-9-and-12-in-human-cytotrophoblastic-cells-from-normal-and-preeclamptic-placentas-712/

ISSN of the journal0172-780X

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Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas

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