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GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach

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Published in Journal of Oncology. 2012, vol. 2012, p. 468615
Abstract Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell.
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PMID: 22481929
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Article (Published version) (1.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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DELIE SALMON, Florence, PETIGNAT, Patrick, COHEN, Marie-Benoîte. GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach. In: Journal of Oncology, 2012, vol. 2012, p. 468615. https://archive-ouverte.unige.ch/unige:31909

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Deposited on : 2013-12-09

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