Involvement of membrane GRP78 in trophoblastic cell fusion

Fradet, Sarah; Pierredon, Sandra; Ribaux, Pascale Garlonne; Epiney, Manuela; Shin Ya, Kazuo; Irion, Olivier; Cohen, Marie-Benoîte

doi:10.1371/journal.pone.0040596

Scientific article

English

Involvement of membrane GRP78 in trophoblastic cell fusion

ContributorsFradet, Sarah; Pierredon, Sandra; Ribaux, Pascale Garlonne; Epiney, Manuela; Shin Ya, Kazuo; Irion, Olivier; Cohen, Marie-Benoîte

Published inPloS one, vol. 7, no. 8, e40596

Publication date2012

Abstract

Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated.

Keywords

Adult
Cell Fusion
Cell Line, Tumor
Chorionic Gonadotropin/secretion
Down-Regulation/drug effects
Female
Forskolin/pharmacology
Heat-Shock Proteins/genetics/metabolism
Humans
Pre-Eclampsia/genetics/metabolism/pathology
Pregnancy
Pregnancy Trimester, First/genetics/metabolism
Trophoblasts/cytology/drug effects/metabolism/pathology

Affiliation entities

Research groups

Laboratoire de biologie des tumeurs gynécologiques et du développement (927)

Citation (ISO format)

FRADET, Sarah et al. Involvement of membrane GRP78 in trophoblastic cell fusion. In: PloS one, 2012, vol. 7, n° 8, p. e40596. doi: 10.1371/journal.pone.0040596

Article (Published version)

CC BY

Identifiers

PID : unige:31825
DOI : 10.1371/journal.pone.0040596
PMID : 22912664

Journal ISSN1932-6203

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Involvement of membrane GRP78 in trophoblastic cell fusion

Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated.

Technical informations