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Scientific article
English

PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

Published inJournal of hepatology, vol. 59, no. 3, p. 420-426
Publication date2013
Abstract

Hepatitis C virus (HCV) infection is dependent on lipid metabolism. Hepatocyte steatosis occurs frequently in HCV infection, but the relationship between steatosis and HCV life cycle is unclear. We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production.

Citation (ISO format)
PEYROU, Marion et al. PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism. In: Journal of hepatology, 2013, vol. 59, n° 3, p. 420–426. doi: 10.1016/j.jhep.2013.04.012
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ISSN of the journal0168-8278
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Creation11/06/2013 10:16:00 AM
First validation11/06/2013 10:16:00 AM
Update time03/14/2023 8:37:56 PM
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