PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

Peyrou, Marion; Clement, Sophie; Maier, Christiane; Bourgoin, Lucie; Branche, Emilie; Conzelmann, Stéphanie; Kaddai, Vincent; Foti, Michelangelo; Negro, Francesco

doi:10.1016/j.jhep.2013.04.012

Scientific article

English

PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

ContributorsPeyrou, Marion; Clement, Sophie; Maier, Christiane; Bourgoin, Lucie; Branche, Emilie; Conzelmann, Stéphanie; Kaddai, Vincent; Foti, Michelangelo

; Negro, Francesco

Published inJournal of hepatology, vol. 59, no. 3, p. 420-426

Publication date2013

Abstract

Hepatitis C virus (HCV) infection is dependent on lipid metabolism. Hepatocyte steatosis occurs frequently in HCV infection, but the relationship between steatosis and HCV life cycle is unclear. We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production.

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Citation (ISO format)

PEYROU, Marion et al. PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism. In: Journal of hepatology, 2013, vol. 59, n° 3, p. 420–426. doi: 10.1016/j.jhep.2013.04.012

Article (Published version)

Identifiers

PID : unige:31271
DOI : 10.1016/j.jhep.2013.04.012
PMID : 23623999

Journal ISSN0168-8278

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PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

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