PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

Peyrou, Marion; Clement, Sophie; Maier, Christiane; Bourgoin, Lucie; Branche, Emilie; Conzelmann, Stéphanie; Kaddai, Vincent; Foti, Michelangelo; Negro, Francesco

doi:10.1016/j.jhep.2013.04.012

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Title		PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism
Authors		Peyrou, Marion Clement, Sophie Maier, Christiane Bourgoin, Lucie Branche, Emilie Conzelmann, Stéphanie Kaddai, Vincent Foti, Michelangelo Negro, Francesco show all authors [1 - 9]
Published in		Journal of Hepatology. 2013, vol. 59, no. 3, p. 420-6
Abstract		Hepatitis C virus (HCV) infection is dependent on lipid metabolism. Hepatocyte steatosis occurs frequently in HCV infection, but the relationship between steatosis and HCV life cycle is unclear. We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production.
Identifiers		DOI: 10.1016/j.jhep.2013.04.012 PMID: 23623999
Full text		Article (Published version) (1.1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Etudes et traitement de l'hépatite C et B (554) Obésité et syndrome métabolique (803)
Citation (ISO format)		PEYROU, Marion et al. PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism. In: Journal of Hepatology, 2013, vol. 59, n° 3, p. 420-6. doi: 10.1016/j.jhep.2013.04.012 https://archive-ouverte.unige.ch/unige:31271