PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

Article Article scientifique Article PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism eng 2013 author Peyrou Marion 565861 author Clement Sophie 759123 author Maier Christiane 734759 author Bourgoin Lucie 683216 author Branche Emilie 747719 author Conzelmann Stéphanie 638487 author Kaddai Vincent 698428 author Foti Michelangelo 0000-0001-7199-4135 28033 author Negro Francesco 96509 420-426 10.1016/j.jhep.2013.04.012 23623999 0168-8278 Hepatitis C virus (HCV) infection is dependent on lipid metabolism. Hepatocyte steatosis occurs frequently in HCV infection, but the relationship between steatosis and HCV life cycle is unclear. We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production. Dewey 612 Dewey 616.07 134 Département de physiologie cellulaire et métabolisme 21C 137 Département de pathologie et immunologie 21F false 297 Etudes et traitement de l'hépatite C et B 554 472 Obésité et syndrome métabolique 803 Journal of hepatology 59 3 b672d022-150d-424d-b4a7-679e4c29b1f3 Article (Published version) Restricted Peyrou et al, JHEPAT, 2013.pdf 1159769 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism	Journal of hepatology			2013	713	2

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Maier, Christiane