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Title

Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus
Authors
Anastaze, Karine
Belli, Dominique Charles
Parvex, Paloma Maria
Girardin, Eric
Giroud Rivier, Alexa
Wildhaber, Barbara
Mclin, Valérie Anne
Published in Pediatric transplantation. 2012, vol. 16, no. 3, p. 250-6
Abstract The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels.
Keywords Adolescent — Antihypertensive Agents/pharmacology — Child — Child, Preschool — Chlorides/pharmacology — Chromium Compounds/pharmacology — Female — Humans — Immunosuppressive Agents/pharmacology — Infant — Kidney Glomerulus/drug effects/pathology — Kidney Tubules/drug effects/pathology — Liver/drug effects — Liver Transplantation/methods — Male — Retrospective Studies — Tacrolimus/pharmacology — Time Factors — Treatment Outcome
Identifiers
PMID: 22176490
Full text
Article (Published version) (183 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups Développement du tube digestif chez les vertébrés (900)
Gastroentérologie et transplantation (pédiatrie) (181)
Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
Recherche clinique en chirurgie pédiatrique (886)
Citation
(ISO format) 		ANASTAZE, Karine et al. Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus. In: Pediatric transplantation, 2012, vol. 16, n° 3, p. 250-6. doi: 10.1111/j.1399-3046.2011.01625.x https://archive-ouverte.unige.ch/unige:31208

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Deposited on : 2013-11-20

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