en
Scientific article
English

Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus

Published inPediatric transplantation, vol. 16, no. 3, p. 250-256
Publication date2012
Abstract

The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels.

Keywords
  • Adolescent
  • Antihypertensive Agents/pharmacology
  • Child
  • Child, Preschool
  • Chlorides/pharmacology
  • Chromium Compounds/pharmacology
  • Female
  • Humans
  • Immunosuppressive Agents/pharmacology
  • Infant
  • Kidney Glomerulus/drug effects/pathology
  • Kidney Tubules/drug effects/pathology
  • Liver/drug effects
  • Liver Transplantation/methods
  • Male
  • Retrospective Studies
  • Tacrolimus/pharmacology
  • Time Factors
  • Treatment Outcome
Citation (ISO format)
ANASTAZE, Karine et al. Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus. In: Pediatric transplantation, 2012, vol. 16, n° 3, p. 250–256. doi: 10.1111/j.1399-3046.2011.01625.x
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Article (Published version)
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ISSN of the journal1397-3142
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