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Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus

Published in Pediatric transplantation. 2012, vol. 16, no. 3, p. 250-6
Abstract The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels.
Keywords AdolescentAntihypertensive Agents/pharmacologyChildChild, PreschoolChlorides/pharmacologyChromium Compounds/pharmacologyFemaleHumansImmunosuppressive Agents/pharmacologyInfantKidney Glomerulus/drug effects/pathologyKidney Tubules/drug effects/pathologyLiver/drug effectsLiver Transplantation/methodsMaleRetrospective StudiesTacrolimus/pharmacologyTime FactorsTreatment Outcome
PMID: 22176490
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Research groups Développement du tube digestif chez les vertébrés (900)
Gastroentérologie et transplantation (pédiatrie) (181)
Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
Recherche clinique en chirurgie pédiatrique (886)
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ANASTAZE, Karine et al. Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus. In: Pediatric transplantation, 2012, vol. 16, n° 3, p. 250-6. doi: 10.1111/j.1399-3046.2011.01625.x https://archive-ouverte.unige.ch/unige:31208

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Deposited on : 2013-11-20

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