Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus

Article Article scientifique Article Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus eng 2012 author Anastaze Karine 582988 author Belli Dominique Charles 26369 author Parvex Paloma Maria 36046 author Girardin Eric 25598 author Giroud Rivier Alexa 651793 author Wildhaber Barbara 595596 author Mclin Valérie Anne 799651 250-256 10.1111/j.1399-3046.2011.01625.x 22176490 1397-3142 The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p = 0.003), with a trend toward significance between pre-OLT and 36 months (p = 0.17). There was no correlation between CrCl and TAC troughs (p = 0.783). Sixteen percent of patients had CrCl <60 mL/min/1.73 m(2) pre-OLT vs. none at 36 months post-OLT. TRP values were normal throughout the study. UPr/Cr decreased insignificantly over time and correlated significantly with TAC trough levels (p = 0.031). UCa/Cr values normalized by the third-month post-OLT, decreasing significantly over the time (p = 0.000) but did not correlate with TAC troughs. At three months post-OLT, 65.2% of patients needed antihypertensive therapy, and no patients needed more than one antihypertensive treatment after one yr. Despite nephrotoxic side effects in the early postoperative phase, this study shows that 65.5% patients had a normal renal function by three yr post-OLT. Tubular indices correlated with TAC trough levels. Adolescent Antihypertensive Agents/pharmacology Child Child, Preschool Chlorides/pharmacology Chromium Compounds/pharmacology Female Humans Immunosuppressive Agents/pharmacology Infant Kidney Glomerulus/drug effects/pathology Kidney Tubules/drug effects/pathology Liver/drug effects Liver Transplantation/methods Male Retrospective Studies Tacrolimus/pharmacology Time Factors Treatment Outcome Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 559 Pathologies hépatiques congénitales et acquises de l'enfant 900 147 Gastroentérologie et transplantation (pédiatrie) 181 146 Pathogénèse du syndrome néphrotique idiopathique de l'enfant 180 546 Recherche clinique en chirurgie pédiatrique 886 Pediatric transplantation 16 3 df235a83-c404-40c8-b101-312edcf4bb98 Article (Published version) Restricted 250-256[1].pdf 187751 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus	Pediatric transplantation			2012	651	0

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Giroud Rivier, Alexa