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Evaluation of S-values and dose distributions for (90)Y, (131)I, (166)Ho, and (188)Re in seven lobes of the rat liver

Published in Medical Physics. 2012, vol. 39, no. 3, p. 1462-72
Abstract Rats have been widely used in radionuclide therapy research for the treatment of hepatocellular carcinoma (HCC). This has created the need to assess rat liver absorbed radiation dose. In most dose estimation studies, the rat liver is considered as a homogeneous integrated target organ with a tissue composition assumed to be similar to that of human liver tissue. However, the rat liver is composed of several lobes having different anatomical and chemical characteristics. To assess the overall impact on rat liver dose calculation, the authors use a new voxel-based rat model with identified suborgan regions of the liver.
Keywords AnimalsCarcinoma, Hepatocellular/radiotherapyElectronsHolmium/therapeutic useIodine Radioisotopes/therapeutic useLiver/radiation effectsLiver Neoplasms/radiotherapyMonte Carlo MethodPhotons/therapeutic useRadiation DosageRatsRats, Sprague-DawleyRhenium/therapeutic useYttrium Radioisotopes/therapeutic use
PMID: 22380379
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Article (Published version) (3.3 MB) - public document Free access
Research group Imagerie Médicale (TEP et TEMP) (542)
Project FNS: 31003A-135576
(ISO format)
XIE, Tianwu, LIU, Qian, ZAIDI, Habib. Evaluation of S-values and dose distributions for (90)Y, (131)I, (166)Ho, and (188)Re in seven lobes of the rat liver. In: Medical Physics, 2012, vol. 39, n° 3, p. 1462-72. doi: 10.1118/1.3681009 https://archive-ouverte.unige.ch/unige:30822

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Deposited on : 2013-10-30

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