Evaluation of S-values and dose distributions for (90)Y, (131)I, (166)Ho, and (188)Re in seven lobes of the rat liver

Article Article scientifique Article Evaluation of S-values and dose distributions for (90)Y, (131)I, (166)Ho, and (188)Re in seven lobes of the rat liver eng 2012 author Xie Tianwu 759229 author Liu Qian 753418 author Zaidi Habib 0000-0001-7559-5297 98447 1462-1472 10.1118/1.3681009 22380379 0094-2405 Rats have been widely used in radionuclide therapy research for the treatment of hepatocellular carcinoma (HCC). This has created the need to assess rat liver absorbed radiation dose. In most dose estimation studies, the rat liver is considered as a homogeneous integrated target organ with a tissue composition assumed to be similar to that of human liver tissue. However, the rat liver is composed of several lobes having different anatomical and chemical characteristics. To assess the overall impact on rat liver dose calculation, the authors use a new voxel-based rat model with identified suborgan regions of the liver. Animals Carcinoma, Hepatocellular/radiotherapy Electrons Holmium/therapeutic use Iodine Radioisotopes/therapeutic use Liver/radiation effects Liver Neoplasms/radiotherapy Monte Carlo Method Photons/therapeutic use Radiation Dosage Rats Rats, Sprague-Dawley Rhenium/therapeutic use Yttrium Radioisotopes/therapeutic use Dewey 616.0757 Swiss National Science Foundation 31003A-135576 CH 62 Département de radiologie et informatique médicale 227 false 287 Imagerie Médicale (TEP et TEMP) 542 Medical physics 39 3 e8190dd0-f9ca-47a3-a3f2-423a45158887 Article (Published version) Public MedPhys2012.pdf 3445875 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Evaluation of S-values and dose distributions for (90)Y, (131)I, (166)Ho, and (188)Re in seven lobes of the rat liver	Medical physics			2012	634	737

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