ARF1 regulates Nef-induced CD4 degradation

Faure, Julien; Stalder Monney, Romaine; Borel, Christelle; Sobo, Komla; Piguet, Vincent; Demaurex, Nicolas; Gruenberg, Jean; Trono, Didier

doi:10.1016/j.cub.2004.06.021

Scientific article

English

ARF1 regulates Nef-induced CD4 degradation

ContributorsFaure, Julien; Stalder Monney, Romaine; Borel, Christelle; Sobo, Komla; Piguet, Vincent; Demaurex, Nicolas

; Gruenberg, Jean; Trono, Didier

Published inCurrent biology, vol. 14, no. 12, p. 1056-1064

Publication date2004

Abstract

The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting.

Keywords

ADP-Ribosylation Factor 1/metabolism
Animals
Antigens, CD4/metabolism
Cells, Cultured
Coated Pits, Cell-Membrane/metabolism
Cricetinae
Endocytosis/physiology
Endosomes/metabolism
Fluorescent Antibody Technique
Gene Products, nef/metabolism
Genetic Vectors
HIV
HeLa Cells
Humans
Microscopy, Confocal
Mutation/genetics
Plasmids/genetics
Precipitin Tests
Ubiquitin-Protein Ligases/metabolism
Viral Fusion Proteins
Nef Gene Products, Human Immunodeficiency Virus

Affiliation

Research group

Signaux intracellulaires (210)

Citation (ISO format)

FAURE, Julien et al. ARF1 regulates Nef-induced CD4 degradation. In: Current biology, 2004, vol. 14, n° 12, p. 1056–1064. doi: 10.1016/j.cub.2004.06.021

Article (Published version)

Identifiers

PID : unige:30414
DOI : 10.1016/j.cub.2004.06.021
PMID : 15202998

ISSN of the journal0960-9822

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ARF1 regulates Nef-induced CD4 degradation

The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting.

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