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ARF1 regulates Nef-induced CD4 degradation

Published in Current Biology. 2004, vol. 14, no. 12, p. 1056-64
Abstract The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting.
Keywords ADP-Ribosylation Factor 1/metabolismAnimalsAntigens, CD4/metabolismCells, CulturedCoated Pits, Cell-Membrane/metabolismCricetinaeEndocytosis/physiologyEndosomes/metabolismFluorescent Antibody TechniqueGene Products, nef/metabolismGenetic VectorsHIVHeLa CellsHumansMicroscopy, ConfocalMutation/geneticsPlasmids/geneticsPrecipitin TestsUbiquitin-Protein Ligases/metabolismViral Fusion ProteinsNef Gene Products, Human Immunodeficiency Virus
PMID: 15202998
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Research group Signaux intracellulaires (210)
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FAURE, Julien et al. ARF1 regulates Nef-induced CD4 degradation. In: Current Biology, 2004, vol. 14, n° 12, p. 1056-64. doi: 10.1016/j.cub.2004.06.021 https://archive-ouverte.unige.ch/unige:30414

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Deposited on : 2013-10-16

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