Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
Contributeurs/tricesPiguet, Vincent; Gu, Feng; Foti, Michelangelo ; Demaurex, Nicolas ; Gruenberg, Jean; Carpentier, Jean-Louis; Trono, Didier
Publié dansCell, vol. 97, no. 1, p. 63-73
Date de publication1999
Résumé
Mots-clés
- Amino Acid Sequence
- Animals
- Antigens, CD4/metabolism
- Binding Sites/physiology
- CHO Cells
- Cell Line
- Coatomer Protein
- Cricetinae
- Dipeptides/physiology
- Down-Regulation/physiology
- Endosomes/metabolism/physiology
- Gene Products, nef/physiology
- HIV-1/physiology
- Humans
- Hydrogen-Ion Concentration
- Kidney
- Lysosomes/metabolism/physiology
- Microtubule-Associated Proteins/metabolism/physiology
- Molecular Sequence Data
- Signal Transduction/physiology
- Nef Gene Products, Human Immunodeficiency Virus
Groupe de recherche
Citation (format ISO)
PIGUET, Vincent et al. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. In: Cell, 1999, vol. 97, n° 1, p. 63–73.
Fichiers principaux (1)
Article (Published version)
Identifiants
- PID : unige:30336
- PMID : 10199403
ISSN du journal0092-8674