Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

Novoa, Alexandre; Barluenga Badiola, Sofia; Serba, Christelle; Winssinger, Nicolas

doi:10.1039/c3cc43458c

Scientific article

English

Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

ContributorsNovoa, Alexandre; Barluenga Badiola, Sofia; Serba, Christelle; Winssinger, Nicolas

Published inChemical communications, vol. 49, no. 69, p. 7608-7610

Publication date2013

Abstract

An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosylation sites that were substituted with S-linked glycans.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

NOVOA, Alexandre et al. Solid phase synthesis of glycopeptides using Shoda’s activation of unprotected carbohydrates. In: Chemical communications, 2013, vol. 49, n° 69, p. 7608–7610. doi: 10.1039/c3cc43458c

Article (Published version)

Identifiers

PID : unige:29565
DOI : 10.1039/c3cc43458c

Commercial URLhttp://xlink.rsc.org/?DOI=c3cc43458c

Journal ISSN1359-7345

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Update time14/03/2023 21:23:53

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Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

Technical informations