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Scientific article
English

Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of Natural Product

Published inOrganic letters, vol. 15, no. 16, p. 4270-4273
Publication date2013
Abstract

Asymmetric bromine–lithium exchange has been successfully employed to synthesize bicoumarin chiral building blocks of (+)-isokotanin A and (−)-kotanin in good yields and with an excellent level of enantioselectivity. This is the first reported example of formal syntheses, using this direct methodology, leading to the single (M)-atropoisomer of (+)-isokotanin A and (−)-kotanin building blocks, without any resolution step.

Citation (ISO format)
GRAFF, Julien et al. Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of Natural Product. In: Organic letters, 2013, vol. 15, n° 16, p. 4270–4273. doi: 10.1021/ol4021157
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ISSN of the journal1523-7052
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Creation09/02/2013 5:05:00 PM
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