Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of Natural Product

Article Article scientifique Article Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of Natural Product eng 2013 author Graff Julien 732146 author Debande Thibaut 778531 author Praz Jezabel 592143 author Guenee Laure 115015 author Alexakis Alexandre 123950 4270-4273 10.1021/ol4021157 1523-7052 Asymmetric bromine–lithium exchange has been successfully employed to synthesize bicoumarin chiral building blocks of (+)-isokotanin A and (−)-kotanin in good yields and with an excellent level of enantioselectivity. This is the first reported example of formal syntheses, using this direct methodology, leading to the single (M)-atropoisomer of (+)-isokotanin A and (−)-kotanin building blocks, without any resolution step. Dewey 540 36 Département de chimie organique 141 false Organic letters 15 16 54743911-d8cc-4a35-ba8e-1719a652b3d8 Article (Published version) Restricted ol4021157.pdf 360593 application/pdf restrictedAccess Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

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Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of Natural Product	Organic letters			2013	658	0

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