Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism

Desmeules, Jules Alexandre; Piguet, Valérie; Besson, Marie; Chabert, Jocelyne; Rapiti Aylward, Elisabetta; Rebsamen, Michela; Rossier, Michel; Curtin, François; Dayer, Pierre; Cedraschi, Christine

doi:10.1037/a0025223

Scientific article

Open access

English

Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism

ContributorsDesmeules, Jules Alexandre; Piguet, Valérie; Besson, Marie; Chabert, Jocelyne; Rapiti Aylward, Elisabetta; Rebsamen, Michela; Rossier, Michel; Curtin, François; Dayer, Pierre; Cedraschi, Christine

Published inHealth psychology review, vol. 31, no. 2, p. 242-249

Publication date2012

Abstract

Fibromyalgia (FM) has been related to biochemical alterations, central pain sensitization and psychological distress. Among genetic and environmental hypotheses, a role was suggested for catechol-O-methyl-transferase (COMT), a modulator in the metabolism of monoaminergic neurotransmitters.

Keywords

Adult
Case-Control Studies
Catechol O-Methyltransferase/genetics/metabolism/physiology
Catechols
Depression
Female
Fibromyalgia/genetics/physiopathology/psychology
Genotype
Guaiacol
Humans
Male
Middle Aged
Pain/genetics
Polymorphism, Genetic
Stress, Psychological
Transferases/genetics

Affiliation

Research group

Funding

Swiss National Science Foundation - 4053-104645

Citation (ISO format)

DESMEULES, Jules Alexandre et al. Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism. In: Health psychology review, 2012, vol. 31, n° 2, p. 242–249. doi: 10.1037/a0025223

Article (Published version)

Identifiers

PID : unige:29415
DOI : 10.1037/a0025223
PMID : 21895373

ISSN of the journal1743-7199

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First validation06/25/2013 4:52:00 PM

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Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism

Fibromyalgia (FM) has been related to biochemical alterations, central pain sensitization and psychological distress. Among genetic and environmental hypotheses, a role was suggested for catechol-O-methyl-transferase (COMT), a modulator in the metabolism of monoaminergic neurotransmitters.

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