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Title

Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments

Authors
Hatterer, Eric
Kosco-Vilbois, Marie
Dean, Yann
Published in Arthritis and Rheumatism. 2012, vol. 64, no. 10, p. 3189-98
Abstract The goal of rheumatoid arthritis (RA) treatment is to achieve clinical remission in order to limit structural damage and physical disability. To this end, recent emphasis has been placed on aggressive treatment early in the course of disease with drugs such as anti-tumor necrosis factor (anti-TNF) agents. As T cells are also thought to play an important role in the initiation of RA, we hypothesized that targeting both TNF and T cells would result in better outcomes. The aim of this study was to examine the efficacy of combined therapy with anti-CD3 and anti-TNF in experimental RA.
Keywords AnimalsAntibodies, Monoclonal/pharmacology/therapeutic useAntigens, CD3/immunologyArthritis, Experimental/drug therapy/immunology/pathologyCD4-Positive T-Lymphocytes/drug effects/immunology/pathologyJoints/drug effects/pathologyMiceMice, Inbred DBATreatment OutcomeTumor Necrosis Factor-alpha/immunology
Identifiers
PMID: 22508436
Full text
Article (Published version) (283 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Groupe Reith Walter (pathologie et immunologie) (282)
Mécanisme de l'inflammation articulaire (44)
Citation
(ISO format)
DEPIS, Fabien et al. Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments. In: Arthritis and Rheumatism, 2012, vol. 64, n° 10, p. 3189-98. https://archive-ouverte.unige.ch/unige:29178

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Deposited on : 2013-08-12

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