Scientific article
English

Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments

Published inArthritis and rheumatism, vol. 64, no. 10, p. 3189-3198
Publication date2012
Abstract

The goal of rheumatoid arthritis (RA) treatment is to achieve clinical remission in order to limit structural damage and physical disability. To this end, recent emphasis has been placed on aggressive treatment early in the course of disease with drugs such as anti-tumor necrosis factor (anti-TNF) agents. As T cells are also thought to play an important role in the initiation of RA, we hypothesized that targeting both TNF and T cells would result in better outcomes. The aim of this study was to examine the efficacy of combined therapy with anti-CD3 and anti-TNF in experimental RA.

Keywords
  • Animals
  • Antibodies, Monoclonal/pharmacology/therapeutic use
  • Antigens, CD3/immunology
  • Arthritis, Experimental/drug therapy/immunology/pathology
  • CD4-Positive T-Lymphocytes/drug effects/immunology/pathology
  • Joints/drug effects/pathology
  • Mice
  • Mice, Inbred DBA
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha/immunology
Citation (ISO format)
DEPIS, Fabien et al. Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments. In: Arthritis and rheumatism, 2012, vol. 64, n° 10, p. 3189–3198. doi: 10.1002/art.34497
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0004-3591
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