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Title

Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments
Authors
Depis, Fabien
Hatterer, Eric
Lamacchia, Céline
Waldburger, Jean-Marc
Gabay, Cem
Reith, Walter
Kosco-Vilbois, Marie
Dean, Yann
Published in Arthritis and Rheumatism. 2012, vol. 64, no. 10, p. 3189-98
Abstract The goal of rheumatoid arthritis (RA) treatment is to achieve clinical remission in order to limit structural damage and physical disability. To this end, recent emphasis has been placed on aggressive treatment early in the course of disease with drugs such as anti-tumor necrosis factor (anti-TNF) agents. As T cells are also thought to play an important role in the initiation of RA, we hypothesized that targeting both TNF and T cells would result in better outcomes. The aim of this study was to examine the efficacy of combined therapy with anti-CD3 and anti-TNF in experimental RA.
Keywords Animals — Antibodies, Monoclonal/pharmacology/therapeutic use — Antigens, CD3/immunology — Arthritis, Experimental/drug therapy/immunology/pathology — CD4-Positive T-Lymphocytes/drug effects/immunology/pathology — Joints/drug effects/pathology — Mice — Mice, Inbred DBA — Treatment Outcome — Tumor Necrosis Factor-alpha/immunology
Identifiers
PMID: 22508436
Full text
Article (Published version) (283 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups Groupe Reith Walter (pathologie et immunologie) (282)
Mécanisme de l'inflammation articulaire (44)
Citation
(ISO format) 		DEPIS, Fabien et al. Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments. In: Arthritis and Rheumatism, 2012, vol. 64, n° 10, p. 3189-98. doi: 10.1002/art.34497 https://archive-ouverte.unige.ch/unige:29178

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Deposited on : 2013-08-12

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