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Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion

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Published in Diabetologia. 2013, vol. 56, no. 4, p. 792-802
Abstract Actin and focal adhesion (FA) remodelling are essential for glucose-stimulated insulin secretion (GSIS). Non-muscle myosin II (NM II) isoforms have been implicated in such remodelling in other cell types, and myosin light chain kinase (MLCK) and Rho-associated coiled-coil-containing kinase (ROCK) are upstream regulators of NM II, which is known to be involved in GSIS. The aim of this work was to elucidate the implication and regulation of NM IIA and IIB in beta cell actin and FA remodelling, granule trafficking and GSIS.
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PMID: 23354122
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Article (Author postprint) (6.2 MB) - public document Free access
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Research group Fonction de l'îlot de Langerhans (324)
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AROUS, Caroline, RONDAS, Dieter, HALBAN, Philippe A. Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion. In: Diabetologia, 2013, vol. 56, n° 4, p. 792-802. https://archive-ouverte.unige.ch/unige:28882

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Deposited on : 2013-07-11

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