Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

Manrique-Hoyos, Natalia; Grønborg, Mads; Kreutzfeldt, Mario; Schedensack, Mariann; Kuhlmann, Tanja; Schrick, Christina; Brück, Wolfgang; Urlaub, Henning; Simons, Mikael; Merkler, Doron; Jürgens, Tanja

doi:10.1002/ana.22681

Scientific article

English

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

ContributorsManrique-Hoyos, Natalia; Grønborg, Mads; Kreutzfeldt, Mario; Schedensack, Mariann; Kuhlmann, Tanja; Schrick, Christina; Brück, Wolfgang; Urlaub, Henning; Simons, Mikael; Merkler, Doron; Jürgens, Tanja

Published inAnnals of neurology, vol. 71, no. 2, p. 227-244

Publication date2012

Abstract

To investigate the impact of single or repeated episodes of reversible demyelination on long-term locomotor performance and neuroaxonal integrity, and to analyze the myelin proteome after remyelination and during aging.

Keywords

Aging
Animals
Axons/pathology/ultrastructure
Cuprizone/administration & dosage/toxicity
Demyelinating Diseases/chemically induced/pathology/physiopathology
Disease Models, Animal
Humans
Mice
Mice, Inbred C57BL
Monoamine Oxidase Inhibitors/administration & dosage/toxicity
Motor Skills/drug effects/physiology
Multiple Sclerosis, Chronic Progressive/physiopathology
Myelin Sheath/pathology/physiology
Time Factors

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

La Sclérose en plaques (908)

Citation (ISO format)

MANRIQUE-HOYOS, Natalia et al. Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis. In: Annals of neurology, 2012, vol. 71, n° 2, p. 227–244. doi: 10.1002/ana.22681

Article (Published version)

Identifiers

PID : unige:28432
DOI : 10.1002/ana.22681
PMID : 22367995

Journal ISSN0364-5134

593views

2downloads

Creation27/05/2013 16:28:00

First validation27/05/2013 16:28:00

Update time14/03/2023 21:18:06

Status update14/03/2023 21:18:05

Last indexation30/10/2024 10:37:45

Archive ouverte UNIGE

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

To investigate the impact of single or repeated episodes of reversible demyelination on long-term locomotor performance and neuroaxonal integrity, and to analyze the myelin proteome after remyelination and during aging.

Technical informations