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Role of T-Typa calcium channels in a cellular model of stroke

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Defense Thèse de doctorat : Univ. Genève et Lausanne, 2013 - Neur. 100 - 2013/05/08
Abstract Background: T-type calcium (Cav3.2) channel inhibitors prevent neuronal death during ischemia,but the cytotoxic signals have not been resolved. Results: Cav3.2 channels generate cytotoxic calcium elevations in the cytosol and mitochondria of PC12 cells deprived of oxygen and glucose. Conclusion: calcium transfer from Cav3.2 channels to mitochondria contributes to ischemic toxicity Significance: Cav3.2 channels and the mitochondrial calcium uniporter (MCU) are potential targets for the treatment of stroke.
Keywords IschemiaMitochondriaCav3.2 channelsToxicity
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URN: urn:nbn:ch:unige-282277
Note Thèse en Neurosciences des universités de Genève et de Lausanne
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GOURIOU, Yves. Role of T-Typa calcium channels in a cellular model of stroke. Université de Genève. Thèse, 2013. https://archive-ouverte.unige.ch/unige:28227

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Deposited on : 2013-05-29

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