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Doctoral thesis
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Role of T-Typa calcium channels in a cellular model of stroke

ContributorsGouriou, Yves
Defense date2013-05-08
Abstract

Background: T-type calcium (Cav3.2) channel inhibitors prevent neuronal death during ischemia,but the cytotoxic signals have not been resolved. Results: Cav3.2 channels generate cytotoxic calcium elevations in the cytosol and mitochondria of PC12 cells deprived of oxygen and glucose. Conclusion: calcium transfer from Cav3.2 channels to mitochondria contributes to ischemic toxicity Significance: Cav3.2 channels and the mitochondrial calcium uniporter (MCU) are potential targets for the treatment of stroke.

eng
Keywords
  • Ischemia
  • Mitochondria
  • Cav3.2 channels
  • Toxicity
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
Citation (ISO format)
GOURIOU, Yves. Role of T-Typa calcium channels in a cellular model of stroke. 2013. doi: 10.13097/archive-ouverte/unige:28227
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Creation05/23/2013 5:54:00 PM
First validation05/23/2013 5:54:00 PM
Update time03/14/2023 8:17:19 PM
Status update03/14/2023 8:17:18 PM
Last indexation01/29/2024 7:51:33 PM
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