Article (Published version) (313 Kb) - 
Limited access to UNIGEOther version: http://pubs.acs.org/doi/abs/10.1021/ol400642y
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Scientific Article
unige:27733 
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Direct Trapping of Sterically Encumbered Aluminum Enolates |
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| Authors | ||
| Published in | Organic Letters. 2013, vol. 15, no. 9, p. 2152-2155 | |
| Abstract | The formation of chiral and sterically congested cyclohexanone derivatives has been achieved through a multistep sequence with one single purification step. (n-Butoxymethyl)-diethylamine was identified as a highly efficient reagent for the direct trapping of aluminum enolates. The Lewis acidic character of aluminum suffices to activate the α-aminoether to form in situ an electrophilic iminium species. In return the aluminum enolate is rendered more nucleophilic by coordination of the butoxy group and formation of an aluminate. | |
| Identifiers | DOI: 10.1021/ol400642y | |
| Full text |
Article (Published version) (313 Kb) - Limited access to UNIGE Other version: http://pubs.acs.org/doi/abs/10.1021/ol400642y |
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| Structures | ||
| Citation (ISO format) | BLESCHKE, Christian Alexander et al. Direct Trapping of Sterically Encumbered Aluminum Enolates. In: Organic Letters, 2013, vol. 15, n° 9, p. 2152-2155. https://archive-ouverte.unige.ch/unige:27733 |
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