UNIGE document Scientific Article
previous document  unige:27591  next document
add to browser collection
Title

Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients

Authors
Published in Islets. 2012, vol. 4, no. 3, p. 243-8
Abstract A non-invasive method to image the mass and/or function of human pancreatic islets is needed to monitor the progression of diabetes, and the effect of therapeutic interventions. As yet, no method is available for this purpose, which could be applied to in situ human islets. Animal and in vitro studies have documented that manganese infusion could improve the magnetic resonance imaging (MRI) of the endocrine pancreas. Here, we have tested whether a similar approach could discriminate diabetic and non-diabetic patients. In vitro, human isolated islets readily incorporated manganese. In vivo, 243 manganese-enhanced magnetic resonance imaging (MEMRI) examinations were reviewed, including 41 examinations which were run on 24 patients with type 2 diabetes and 202 examinations which were run on 119 normoglycemic patients. The results show that MEMRI discriminates type 2 diabetics from non-diabetic patients, based on the signal enhancement of pancreas.
Keywords AdolescentAdultAgedAged, 80 and overCohort StudiesDiabetes Mellitus, Type 2/diagnosis/metabolismEdetic Acid/analogs & derivatives/pharmacologyFemaleHumansImage Enhancement/methodsInsulin-Secreting Cells/metabolismMagnetic Resonance Imaging/methodsMaleMiddle AgedPyridoxal Phosphate/analogs & derivatives/pharmacologyRetrospective StudiesYoung Adult
Identifiers
PMID: 22722479
Full text
Article (Published version) (514 Kb) - public document Free access
Structures
Research groups La transplantation d'îlots de Langerhans (623)
Imagerie et radiologie interventionnelle du foie, des voies biliaires et du pancréas (316)
Couplage cellulaire et connexines (136)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
Citation
(ISO format)
BOTSIKAS, Diomidis et al. Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients. In: Islets, 2012, vol. 4, n° 3, p. 243-8. https://archive-ouverte.unige.ch/unige:27591

224 hits

112 downloads

Update

Deposited on : 2013-04-26

Export document
Format :
Citation style :