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Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients

Published in Islets. 2012, vol. 4, no. 3, p. 243-8
Abstract A non-invasive method to image the mass and/or function of human pancreatic islets is needed to monitor the progression of diabetes, and the effect of therapeutic interventions. As yet, no method is available for this purpose, which could be applied to in situ human islets. Animal and in vitro studies have documented that manganese infusion could improve the magnetic resonance imaging (MRI) of the endocrine pancreas. Here, we have tested whether a similar approach could discriminate diabetic and non-diabetic patients. In vitro, human isolated islets readily incorporated manganese. In vivo, 243 manganese-enhanced magnetic resonance imaging (MEMRI) examinations were reviewed, including 41 examinations which were run on 24 patients with type 2 diabetes and 202 examinations which were run on 119 normoglycemic patients. The results show that MEMRI discriminates type 2 diabetics from non-diabetic patients, based on the signal enhancement of pancreas.
Keywords AdolescentAdultAgedAged, 80 and overCohort StudiesDiabetes Mellitus, Type 2/diagnosis/metabolismEdetic Acid/analogs & derivatives/pharmacologyFemaleHumansImage Enhancement/methodsInsulin-Secreting Cells/metabolismMagnetic Resonance Imaging/methodsMaleMiddle AgedPyridoxal Phosphate/analogs & derivatives/pharmacologyRetrospective StudiesYoung Adult
PMID: 22722479
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Research groups Couplage cellulaire et connexines (136)
Imagerie et radiologie interventionnelle du foie, des voies biliaires et du pancréas (316)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
La transplantation d'îlots de Langerhans (623)
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BOTSIKAS, Diomidis et al. Pancreatic magnetic resonance imaging after manganese injection distinguishes type 2 diabetic and normoglycemic patients. In: Islets, 2012, vol. 4, n° 3, p. 243-8. doi: 10.4161/isl.20857 https://archive-ouverte.unige.ch/unige:27591

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Deposited on : 2013-04-26

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