UNIGE document Scientific Article
previous document  unige:27585  next document
add to browser collection
Title

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Authors
Di Marzo, Vincenzo
da Silva, Rafaela F
Capettini, Luciano
Piscitelli, Fabiana
show hidden authors show all authors [1 - 28]
Published in European Heart Journal. 2012, vol. 33, no. 7, p. 846-56
Abstract The activation of cannabinoid receptor type 2 (CB(2))-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB(2) pharmacological activation on markers of plaque vulnerability in vivo and in vitro.
Keywords AgedAnimalsAorta, Thoracic/metabolismCannabinoids/pharmacologyCarotid Artery, Internal/metabolismCarotid Stenosis/metabolismCase-Control StudiesFemaleFlavonoids/pharmacologyHumansIndoles/pharmacologyMAP Kinase Signaling System/physiologyMaleMatrix Metalloproteinase 9/metabolism/physiologyMiceMice, Inbred C57BLNeutrophils/metabolismPhosphorylation/physiologyPlaque, Atherosclerotic/metabolismProtein Kinase Inhibitors/pharmacologyReceptor, Cannabinoid, CB2/antagonists & inhibitors/metabolismTumor Necrosis Factor-alpha/metabolism
Identifiers
PMID: 22112961
Full text
Article (Published version) (498 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Epidémiologie clinique (115)
Chimie et protéomique clinique (270)
Citation
(ISO format)
MONTECUCCO, Fabrizio et al. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. In: European Heart Journal, 2012, vol. 33, n° 7, p. 846-56. https://archive-ouverte.unige.ch/unige:27585

274 hits

2 downloads

Update

Deposited on : 2013-04-26

Export document
Format :
Citation style :