The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Montecucco, Fabrizio; Di Marzo, Vincenzo; da Silva, Rafaela F; Vuilleumier, Nicolas; Capettini, Luciano; Lenglet, Sébastien; Pagano, Sabrina; Piscitelli, Fabiana; Quintao, Silvia; Bertolotto, Maria; Pelli, Graziano; Galan, Katia; Pilet, Lucie; Kuzmanovic, Kristina; Burger, Fabienne; Pane, Bianca; Spinella, Giovanni; Braunersreuther, Vincent; Gayet-Ageron, Angèle; Pende, Aldo; Viviani, Giorgio Luciano; Palombo, Domenico; Dallegri, Franco; Roux-Lombard, Pascale; Santos, Robson A S; Stergiopulos, Nikos; Steffens, Sabine; Mach, François

doi:10.1093/eurheartj/ehr449

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Title		The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques
Authors		Montecucco, Fabrizio Di Marzo, Vincenzo da Silva, Rafaela F Vuilleumier, Nicolas Capettini, Luciano Lenglet, Sébastien Pagano, Sabrina Piscitelli, Fabiana Quintao, Silvia Bertolotto, Maria Pelli, Graziano Galan, Katia Pilet, Lucie Kuzmanovic, Kristina Burger, Fabienne Pane, Bianca Spinella, Giovanni Braunersreuther, Vincent Gayet-Ageron, Angèle Pende, Aldo Viviani, Giorgio Luciano Palombo, Domenico Dallegri, Franco Roux-Lombard, Pascale Santos, Robson A S Stergiopulos, Nikos Steffens, Sabine Mach, François show all authors [1 - 28]
Published in		European heart journal. 2012, vol. 33, no. 7, p. 846-56
Abstract		The activation of cannabinoid receptor type 2 (CB(2))-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB(2) pharmacological activation on markers of plaque vulnerability in vivo and in vitro.
Keywords		Aged — Animals — Aorta, Thoracic/metabolism — Cannabinoids/pharmacology — Carotid Artery, Internal/metabolism — Carotid Stenosis/metabolism — Case-Control Studies — Female — Flavonoids/pharmacology — Humans — Indoles/pharmacology — MAP Kinase Signaling System/physiology — Male — Matrix Metalloproteinase 9/metabolism/physiology — Mice — Mice, Inbred C57BL — Neutrophils/metabolism — Phosphorylation/physiology — Plaque, Atherosclerotic/metabolism — Protein Kinase Inhibitors/pharmacology — Receptor, Cannabinoid, CB2/antagonists & inhibitors/metabolism — Tumor Necrosis Factor-alpha/metabolism
Identifiers		DOI: 10.1093/eurheartj/ehr449 PMID: 22112961
Full text		Article (Published version) (498 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires
Research groups		Chimie et protéomique clinique (270) Epidémiologie clinique (115) Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Citation (ISO format)		MONTECUCCO, Fabrizio et al. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. In: European heart journal, 2012, vol. 33, n° 7, p. 846-56. doi: 10.1093/eurheartj/ehr449 https://archive-ouverte.unige.ch/unige:27585