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The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques |
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Published in | European heart journal. 2012, vol. 33, no. 7, p. 846-56 | |
Abstract | The activation of cannabinoid receptor type 2 (CB(2))-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB(2) pharmacological activation on markers of plaque vulnerability in vivo and in vitro. | |
Keywords | Aged — Animals — Aorta, Thoracic/metabolism — Cannabinoids/pharmacology — Carotid Artery, Internal/metabolism — Carotid Stenosis/metabolism — Case-Control Studies — Female — Flavonoids/pharmacology — Humans — Indoles/pharmacology — MAP Kinase Signaling System/physiology — Male — Matrix Metalloproteinase 9/metabolism/physiology — Mice — Mice, Inbred C57BL — Neutrophils/metabolism — Phosphorylation/physiology — Plaque, Atherosclerotic/metabolism — Protein Kinase Inhibitors/pharmacology — Receptor, Cannabinoid, CB2/antagonists & inhibitors/metabolism — Tumor Necrosis Factor-alpha/metabolism | |
Identifiers | PMID: 22112961 | |
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Research groups | Chimie et protéomique clinique (270) Epidémiologie clinique (115) Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779) | |
Citation (ISO format) | MONTECUCCO, Fabrizio et al. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. In: European heart journal, 2012, vol. 33, n° 7, p. 846-56. doi: 10.1093/eurheartj/ehr449 https://archive-ouverte.unige.ch/unige:27585 |