The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Article Article scientifique Article The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques eng 2012 author Montecucco Fabrizio 651324 author Di Marzo Vincenzo author da Silva Rafaela F author Vuilleumier Nicolas 61406 author Capettini Luciano author Lenglet Sébastien 589285 author Pagano Sabrina 0000-0001-7075-1182 758239 author Piscitelli Fabiana author Quintao Silvia author Bertolotto Maria author Pelli Graziano 105578 author Galan Katia 123632 author Pilet Lucie 659644 author Kuzmanovic Kristina 657245 author Burger Fabienne 97461 author Pane Bianca author Spinella Giovanni author Braunersreuther Vincent 510607 author Gayet-Ageron Angèle 668551 author Pende Aldo author Viviani Giorgio Luciano author Palombo Domenico author Dallegri Franco author Roux-Lombard Pascale 22481 author Santos Robson A S author Stergiopulos Nikos author Steffens Sabine 135223 author Mach François 27365 846-856 10.1093/eurheartj/ehr449 22112961 0195-668X The activation of cannabinoid receptor type 2 (CB(2))-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB(2) pharmacological activation on markers of plaque vulnerability in vivo and in vitro. Aged Animals Aorta, Thoracic/metabolism Cannabinoids/pharmacology Carotid Artery, Internal/metabolism Carotid Stenosis/metabolism Case-Control Studies Female Flavonoids/pharmacology Humans Indoles/pharmacology MAP Kinase Signaling System/physiology Male Matrix Metalloproteinase 9/metabolism/physiology Mice Mice, Inbred C57BL Neutrophils/metabolism Phosphorylation/physiology Plaque, Atherosclerotic/metabolism Protein Kinase Inhibitors/pharmacology Receptor, Cannabinoid, CB2/antagonists & inhibitors/metabolism Tumor Necrosis Factor-alpha/metabolism Dewey 613 Dewey 616 Dewey 616.07 Dewey 576 136 Département de biologie structurale et bioinformatique 21E 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 64 Département de santé et médecine communautaires 22A false 211 Auto-immunité, inflammation et athérosclérose 270 88 Epidémiologie clinique 115 449 Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles 779 European heart journal 33 7 e931238d-bf0b-4e60-8ec2-4e18a0c998d6 Article (Published version) Restricted Montecucco F. - the European Society of Cardiology - 2012.pdf 509849 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires

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The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques	European heart journal			2012	750	0

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Kuzmanovic, Kristina