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Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex |
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Published in | Journal of internal medicine. 2012, vol. 272, no. 4, p. 344-57 | |
Abstract | Toll-like receptor (TLR)-mediated vascular inflammation, inducible by - amongst other factors - auto-antibodies, is increasingly recognized as a potential mediator of cardiovascular disease. We investigated whether anti-apolipoprotein (Apo)A-1 IgG was associated with a pro-inflammatory cytokine profile in myocardial infarction (MI) patients and whether anti-ApoA-1 IgG elicited a pro-inflammatory response by activating TLRs. | |
Keywords | Adult — Aged — Aged, 80 and over — Antigens, CD14/immunology — Apolipoprotein A-I/immunology — Autoantibodies/immunology — Female — Humans — Immunoglobulin G/immunology — Inflammation/immunology — Male — Middle Aged — Myocardial Infarction/complications/immunology — Toll-Like Receptor 2/immunology | |
Identifiers | PMID: 22329401 | |
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Research groups | Chimie et protéomique clinique (270) Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779) | |
Citation (ISO format) | PAGANO, Sabrina et al. Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex. In: Journal of internal medicine, 2012, vol. 272, n° 4, p. 344-57. doi: 10.1111/j.1365-2796.2012.02530.x https://archive-ouverte.unige.ch/unige:27583 |