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Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex

ContributorsPagano, Sabrinaorcid; Satta Poschung, Nathalie; Werling, D; Offord, Valérie Edna; De Moerloose, Philippe; Charbonney, Emmanuel; Hochstrasser, Denis; Roux-Lombard, Pascale; Vuilleumier, Nicolas
Published inJournal of internal medicine, vol. 272, no. 4, p. 344-357
Publication date2012
Abstract

Toll-like receptor (TLR)-mediated vascular inflammation, inducible by - amongst other factors - auto-antibodies, is increasingly recognized as a potential mediator of cardiovascular disease. We investigated whether anti-apolipoprotein (Apo)A-1 IgG was associated with a pro-inflammatory cytokine profile in myocardial infarction (MI) patients and whether anti-ApoA-1 IgG elicited a pro-inflammatory response by activating TLRs.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD14/immunology
  • Apolipoprotein A-I/immunology
  • Autoantibodies/immunology
  • Female
  • Humans
  • Immunoglobulin G/immunology
  • Inflammation/immunology
  • Male
  • Middle Aged
  • Myocardial Infarction/complications/immunology
  • Toll-Like Receptor 2/immunology
Affiliation
Research group
Citation (ISO format)
PAGANO, Sabrina et al. Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex. In: Journal of internal medicine, 2012, vol. 272, n° 4, p. 344–357. doi: 10.1111/j.1365-2796.2012.02530.x
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accessLevelRestricted
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ISSN of the journal0954-6820
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