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Title

Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex

Authors
Werling, D
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Published in Journal of Internal Medicine. 2012, vol. 272, no. 4, p. 344-57
Abstract Toll-like receptor (TLR)-mediated vascular inflammation, inducible by - amongst other factors - auto-antibodies, is increasingly recognized as a potential mediator of cardiovascular disease. We investigated whether anti-apolipoprotein (Apo)A-1 IgG was associated with a pro-inflammatory cytokine profile in myocardial infarction (MI) patients and whether anti-ApoA-1 IgG elicited a pro-inflammatory response by activating TLRs.
Keywords AdultAgedAged, 80 and overAntigens, CD14/immunologyApolipoprotein A-I/immunologyAutoantibodies/immunologyFemaleHumansImmunoglobulin G/immunologyInflammation/immunologyMaleMiddle AgedMyocardial Infarction/complications/immunologyToll-Like Receptor 2/immunology
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PMID: 22329401
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Research groups Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Chimie et protéomique clinique (270)
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PAGANO, Sabrina et al. Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex. In: Journal of Internal Medicine, 2012, vol. 272, n° 4, p. 344-57. https://archive-ouverte.unige.ch/unige:27583

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Deposited on : 2013-04-26

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