Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex

Pagano, Sabrina; Satta Poschung, Nathalie; Werling, D; Offord, Valérie Edna; De Moerloose, Philippe; Charbonney, Emmanuel; Hochstrasser, Denis; Roux-Lombard, Pascale; Vuilleumier, Nicolas

doi:10.1111/j.1365-2796.2012.02530.x

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Title		Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex
Authors		Pagano, Sabrina Satta Poschung, Nathalie Werling, D Offord, Valérie Edna De Moerloose, Philippe Charbonney, Emmanuel Hochstrasser, Denis Roux-Lombard, Pascale Vuilleumier, Nicolas show all authors [1 - 9]
Published in		Journal of internal medicine. 2012, vol. 272, no. 4, p. 344-57
Abstract		Toll-like receptor (TLR)-mediated vascular inflammation, inducible by - amongst other factors - auto-antibodies, is increasingly recognized as a potential mediator of cardiovascular disease. We investigated whether anti-apolipoprotein (Apo)A-1 IgG was associated with a pro-inflammatory cytokine profile in myocardial infarction (MI) patients and whether anti-ApoA-1 IgG elicited a pro-inflammatory response by activating TLRs.
Keywords		Adult — Aged — Aged, 80 and over — Antigens, CD14/immunology — Apolipoprotein A-I/immunology — Autoantibodies/immunology — Female — Humans — Immunoglobulin G/immunology — Inflammation/immunology — Male — Middle Aged — Myocardial Infarction/complications/immunology — Toll-Like Receptor 2/immunology
Identifiers		DOI: 10.1111/j.1365-2796.2012.02530.x PMID: 22329401
Full text		Article (Published version) (644 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups		Chimie et protéomique clinique (270) Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Citation (ISO format)		PAGANO, Sabrina et al. Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex. In: Journal of internal medicine, 2012, vol. 272, n° 4, p. 344-57. doi: 10.1111/j.1365-2796.2012.02530.x https://archive-ouverte.unige.ch/unige:27583