Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex

Article Article scientifique Article Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex eng 2012 author Pagano Sabrina 0000-0001-7075-1182 758239 author Satta Poschung Nathalie 134524 author Werling D author Offord Valérie Edna 22201 author De Moerloose Philippe 26335 author Charbonney Emmanuel 561779 author Hochstrasser Denis 26422 author Roux-Lombard Pascale 22481 author Vuilleumier Nicolas 61406 344-357 10.1111/j.1365-2796.2012.02530.x 22329401 0954-6820 Toll-like receptor (TLR)-mediated vascular inflammation, inducible by - amongst other factors - auto-antibodies, is increasingly recognized as a potential mediator of cardiovascular disease. We investigated whether anti-apolipoprotein (Apo)A-1 IgG was associated with a pro-inflammatory cytokine profile in myocardial infarction (MI) patients and whether anti-ApoA-1 IgG elicited a pro-inflammatory response by activating TLRs. Adult Aged Aged, 80 and over Antigens, CD14/immunology Apolipoprotein A-I/immunology Autoantibodies/immunology Female Humans Immunoglobulin G/immunology Inflammation/immunology Male Middle Aged Myocardial Infarction/complications/immunology Toll-Like Receptor 2/immunology Dewey 616 Dewey 576 136 Département de biologie structurale et bioinformatique 21E 56 Département de médecine 221 false 211 Auto-immunité, inflammation et athérosclérose 270 449 Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles 779 Journal of internal medicine 272 4 3c2ae714-076c-45f0-82a0-77dd80b17845 Article (Published version) Restricted Pagano S.- the Journal of Internal Medicine - 2012.pdf 659682 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique Faculté de médecine / Section de médecine clinique / Département de médecine

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Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex	Journal of internal medicine			2012	749	3

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Offord, Valérie Edna