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Title

Quel programme informatique de détection des interactions médicamenteuses néfastes ?

Authors
Reutemann, Barbara
Published in Revue médicale suisse. 2012, vol. 8, no. 358, p. 1978-82
Abstract Adverse drug events (ADE) are a major public health issue, with drug-drug interactions (DDI) being one of well-recognized causes of ADE that could be preventable by the use of DDI screening software. We compared the ability of four programs to detect clinically important DDI. We tested 62 drug pairs with and 12 drug pairs without clinically important DDI. Lexi-Interact and Epocrates were the most sensitive (95%) compared to the Compendium and Theriaque (80 and 73%, respectively). The Compendium and Theriaque also showed the lowest negative predictive value. All programs showed high specificity and positive predictive value. The qualitative assessment showed the best performances for Compendium and Lexi-Interact. The last one seems to be the best screening program, but the Compendium is in French and is freely available.
Keywords Drug Information ServicesDrug InteractionsHumansSoftware
Identifiers
PMID: 23198652
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Article (Published version) (562 Kb) - public document Free access
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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ING LORENZINI, Kuntheavy et al. Quel programme informatique de détection des interactions médicamenteuses néfastes ?. In: Revue médicale suisse, 2012, vol. 8, n° 358, p. 1978-82. https://archive-ouverte.unige.ch/unige:27154

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Deposited on : 2013-04-03

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