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Title

Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice

Authors
Matter, Christian M
Roth, Isabelle
Lüscher, Thomas F
Published in Circulation. 2006, vol. 113, no. 24, p. 2835-43
Abstract Reducing the expression of the gap junction protein connexin43 (Cx43) inhibits the progression of atherosclerosis, a chronic inflammatory disease. Furthermore, acute vascular injury induced by percutaneous coronary interventions is associated with increased Cx43 expression in neointimal smooth muscle cells (SMCs). However, the relevance of Cx43 after acute vascular injury remains unclear.
Keywords Angioplasty, Balloon/adverse effectsAnimalsCarotid Artery Diseases/etiology/therapyCarotid Stenosis/etiology/prevention & controlCell DivisionCell MovementCells, Cultured/secretionChemotactic Factors/secretionCholesterol/bloodConnexin 43/genetics/physiologyDNA ReplicationDiet, AtherogenicEndothelium, Vascular/pathologyHyperlipoproteinemia Type II/blood/complications/geneticsHyperplasiaMacrophages/pathology/secretionMacrophages, Peritoneal/secretionMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, Vascular/pathologyReceptors, LDL/deficiency/geneticsRecurrenceTriglycerides/bloodTunica Intima/pathology
Identifiers
PMID: 16769907
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Structures
Research groups L'athérosclérose (665)
Mucoviscidose et jonctions GAP (229)
Citation
(ISO format)
CHADJICHRISTOS, Christos et al. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. In: Circulation, 2006, vol. 113, n° 24, p. 2835-43. https://archive-ouverte.unige.ch/unige:27038

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Deposited on : 2013-03-26

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