Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice

Article Article scientifique Article Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice eng 2006 author Chadjichristos Christos 135640 author Matter Christian M author Roth Isabelle author Sutter Esther 612399 author Pelli Graziano 105578 author Lüscher Thomas F author Chanson Marc 0000-0001-8104-2090 32865 author Kwak Brenda 113350 2835-2843 10.1161/CIRCULATIONAHA.106.627703 16769907 0009-7322 Reducing the expression of the gap junction protein connexin43 (Cx43) inhibits the progression of atherosclerosis, a chronic inflammatory disease. Furthermore, acute vascular injury induced by percutaneous coronary interventions is associated with increased Cx43 expression in neointimal smooth muscle cells (SMCs). However, the relevance of Cx43 after acute vascular injury remains unclear. Angioplasty, Balloon/adverse effects Animals Carotid Artery Diseases/etiology/therapy Carotid Stenosis/etiology/prevention & control Cell Division Cell Movement Cells, Cultured/secretion Chemotactic Factors/secretion Cholesterol/blood Connexin 43/genetics/physiology DNA Replication Diet, Atherogenic Endothelium, Vascular/pathology Hyperlipoproteinemia Type II/blood/complications/genetics Hyperplasia Macrophages/pathology/secretion Macrophages, Peritoneal/secretion Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular/pathology Receptors, LDL/deficiency/genetics Recurrence Triglycerides/blood Tunica Intima/pathology Dewey 616.07 Dewey 618 137 Département de pathologie et immunologie 21F 58 Département de pédiatrie, gynécologie et obstétrique 223 false 397 Connexines et pathologies cardiovasculaires 665 180 Mucoviscidose et jonctions GAP 229 Circulation 113 24 0d7d6806-5fe3-49ce-a8f2-d750790ff186 Article (Published version) Restricted Chadjichristos-2006-Reduced connexin43 e.pdf 922768 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice	Circulation			2006	616	0

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Sutter, Esther