COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers
|Published in||Journal of Cardiopulmonary Rehabilitation. 2004, vol. 24, no. 5, p. 332-9|
|Abstract||Findings recently have shown coupling protein-3 (UCP3) content to be decreased in the skeletal muscle of patients with chronic obstructive pulmonary disease (COPD). Uncoupling protein-3 mRNA exists as two isoforms: long (UCP3L) and short (UCP3S). The UCP3 protein is expressed the least in oxidative and the most in glycolytic muscle fibers. Levels of UCP3 have been associated positively with intramyocellular triglyceride (IMTG) contents in conditions of altered fatty acid metabolism. As a source for muscle free fatty acid metabolism, IMTG is decreased in COPD. The current study completely characterized all the parameters of UCP3 expression (ie, UCP3L and UCP3S mRNA expression in whole muscle samples) and UCP3 protein content as well as IMTG content in the different fiber types in patients with COPD and healthy control subjects.|
|Keywords||Aged — Carrier Proteins/genetics/metabolism — Case-Control Studies — Humans — Ion Channels — Male — Middle Aged — Mitochondria — Muscle/genetics/metabolism — Mitochondrial Proteins — Muscle Fibers — Fast-Twitch/metabolism — Muscle Fibers — Slow-Twitch/metabolism — Muscle — Skeletal/metabolism — Pulmonary Disease — Chronic Obstructive/genetics/metabolism — RNA — Messenger/metabolism|
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|Research group||HIV (835)|
|RUSSELL, Aaron Paul et al. COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers. In: Journal of Cardiopulmonary Rehabilitation, 2004, vol. 24, n° 5, p. 332-9. doi: 10.1097/00008483-200409000-00009 https://archive-ouverte.unige.ch/unige:27010|