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COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers

Debigaré, Richard
Richard, Denis
Michaud, Annie
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Published in Journal of cardiopulmonary rehabilitation. 2004, vol. 24, no. 5, p. 332-9
Abstract Findings recently have shown coupling protein-3 (UCP3) content to be decreased in the skeletal muscle of patients with chronic obstructive pulmonary disease (COPD). Uncoupling protein-3 mRNA exists as two isoforms: long (UCP3L) and short (UCP3S). The UCP3 protein is expressed the least in oxidative and the most in glycolytic muscle fibers. Levels of UCP3 have been associated positively with intramyocellular triglyceride (IMTG) contents in conditions of altered fatty acid metabolism. As a source for muscle free fatty acid metabolism, IMTG is decreased in COPD. The current study completely characterized all the parameters of UCP3 expression (ie, UCP3L and UCP3S mRNA expression in whole muscle samples) and UCP3 protein content as well as IMTG content in the different fiber types in patients with COPD and healthy control subjects.
Keywords AgedCarrier Proteins/genetics/metabolismCase-Control StudiesHumansIon ChannelsMaleMiddle AgedMitochondriaMuscle/genetics/metabolismMitochondrial ProteinsMuscle FibersFast-Twitch/metabolismMuscle FibersSlow-Twitch/metabolismMuscleSkeletal/metabolismPulmonary DiseaseChronic Obstructive/genetics/metabolismRNAMessenger/metabolism
PMID: 15602154
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RUSSELL, Aaron Paul et al. COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers. In: Journal of cardiopulmonary rehabilitation, 2004, vol. 24, n° 5, p. 332-9. doi: 10.1097/00008483-200409000-00009 https://archive-ouverte.unige.ch/unige:27010

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Deposited on : 2013-03-26

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