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Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation

ContributorsBrown, Matthew; Bellone, Camilla; Mameli, Manuel; Labouebe, Gwenael Pierre; Bocklisch, Christina; Balland, Bénédicte; Dahan, Lionel; Luján, Rafael; Deisseroth, Karl; Luescher, Christian
Published inPloS one, vol. 5, no. 12, e15870
Publication date2010
Abstract

Addictive drugs have in common that they cause surges in dopamine (DA) concentration in the mesolimbic reward system and elicit synaptic plasticity in DA neurons of the ventral tegmental area (VTA). Cocaine for example drives insertion of GluA2-lacking AMPA receptors (AMPARs) at glutamatergic synapes in DA neurons. However it remains elusive which molecular target of cocaine drives such AMPAR redistribution and whether other addictive drugs (morphine and nicotine) cause similar changes through their effects on the mesolimbic DA system.

Keywords
  • Animals
  • Cocaine/pharmacology
  • Dependovirus/metabolism
  • Dopamine/metabolism
  • Electrophysiology/methods
  • Glutamine/metabolism
  • Mice
  • Mice, Inbred C57BL
  • Morphine/pharmacology
  • Neurons/metabolism
  • Nicotine/pharmacology
  • Receptors, AMPA/metabolism
  • Synapses
  • Ventral Tegmental Area/metabolism
Affiliation
Research group
Citation (ISO format)
BROWN, Matthew et al. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. In: PloS one, 2010, vol. 5, n° 12, p. e15870. doi: 10.1371/journal.pone.0015870
Main files (1)
Article (Published version)
accessLevelPublic CC BY
Identifiers
ISSN of the journal1932-6203
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244downloads

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