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Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation

Luján, Rafael
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Published in PloS one. 2010, vol. 5, no. 12, e15870
Abstract Addictive drugs have in common that they cause surges in dopamine (DA) concentration in the mesolimbic reward system and elicit synaptic plasticity in DA neurons of the ventral tegmental area (VTA). Cocaine for example drives insertion of GluA2-lacking AMPA receptors (AMPARs) at glutamatergic synapes in DA neurons. However it remains elusive which molecular target of cocaine drives such AMPAR redistribution and whether other addictive drugs (morphine and nicotine) cause similar changes through their effects on the mesolimbic DA system.
Keywords AnimalsCocaine/pharmacologyDependovirus/metabolismDopamine/metabolismElectrophysiology/methodsGlutamine/metabolismMiceMice, Inbred C57BLMorphine/pharmacologyNeurons/metabolismNicotine/pharmacologyReceptors, AMPA/metabolismSynapsesVentral Tegmental Area/metabolism
PMID: 21209835
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Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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BROWN, Matthew et al. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. In: PloS one, 2010, vol. 5, n° 12, p. e15870. doi: 10.1371/journal.pone.0015870 https://archive-ouverte.unige.ch/unige:26931

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Deposited on : 2013-03-25

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