Diagnosis of and treatment for symptomatic carotid stenosis: an updated review

Momjian-Mayor, I; Burkhard, Pierre; Murith, Nicolas Paul Henri; Mugnai, Damiano; Yilmaz, Hasan; Narata, Ana Paula; Lövblad, Karl-Olof; Mendes Pereira, Vitor; Righini, Marc Philip; Bounameaux, Henri; Sztajzel, Roman

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Title		Diagnosis of and treatment for symptomatic carotid stenosis: an updated review
Authors		Momjian-Mayor, I Burkhard, Pierre Murith, Nicolas Paul Henri Mugnai, Damiano Yilmaz, Hasan Narata, Ana Paula Lövblad, Karl-Olof Mendes Pereira, Vitor Righini, Marc Philip Bounameaux, Henri Sztajzel, Roman show all authors [1 - 11]
Published in		Acta Neurologica Scandinavica. 2012, vol. 126, no. 5, p. 293-305
Abstract		Carotid stenoses of ≥50% account for about 15-20% of strokes. Their degree may be moderate (50-69%) or severe (70-99%). Current diagnostic methods include ultrasound, MR- or CT-angiography. Stenosis severity, irregular plaque surface, and presence of microembolic signals detected by transcranial Doppler predict the early recurrence risk, which may be as high as 20%. Initial therapy comprises antiplatelets and statins. Benefit of revascularization is greater in men, in older patients, and in severe stenosis; patients with moderate stenoses may also profit particularly if the plaque has an irregular aspect. An intervention should be performed within <2 weeks. In large randomized studies comparing endarterectomy and stenting, endovascular therapy was associated with a higher risk of periprocedural stroke, yet in some studies, with a lower risk of myocardial infarction and of cranial neuropathy. These trials support endarterectomy as the first choice treatment. Risk factors for each of the two therapies have been indentified: coronary artery disease, neck radiation, contralateral laryngeal nerve palsy for endarterectomy, and, elderly patients (>70 years), arch vessel tortuosity and plaques with low echogenicity on ultrasound for carotid stenting. Lastly, in direct comparisons, a contralateral occlusion increases the risk of periprocedural complications in both types of treatment.
Identifiers		DOI: 10.1111/j.1600-0404.2012.01672.x PMID: 22607370
Full text		Article (Published version) (273 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups		Geneva Platelet Group (13) Chirurgie cardio-vasculaire (105) Groupe Pierre Burkhard (neurologie) (154)
Citation (ISO format)		MOMJIAN-MAYOR, I et al. Diagnosis of and treatment for symptomatic carotid stenosis: an updated review. In: Acta Neurologica Scandinavica, 2012, vol. 126, n° 5, p. 293-305. https://archive-ouverte.unige.ch/unige:26313