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Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5

Lederman, Michael M
Veazey, Ronald S
Mosier, Donald E
Dufour, Jason
Mefford, Megan
Piatak, Michael (Jr)
Lifson, Jeffrey D
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Published in Science. 2004, vol. 306, no. 5695, p. 485-7
Abstract Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.
Keywords AdministrationIntravaginalAnimalsAnti-HIV Agents/administration & dosage/therapeutic useAnti-Infective AgentsLocal/administration & dosage/therapeutic useAntibodiesViral/bloodChemokine CCL5/administration & dosage/analogs & derivatives/therapeutic useDose-Response RelationshipDrugDrug EvaluationPreclinicalFemaleHIV Infections/prevention & control/transmissionHIV-1/drug effectsMacaca mulattaReceptorsCCR5/antagonists & inhibitors/metabolismSimian Acquired Immunodeficiency Syndrome/prevention & control/transmissionSimian immunodeficiency virus/drug effects/immunologyVagina/virology
PMID: 15486300
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Research group HIV (835)
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LEDERMAN, Michael M et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. In: Science, 2004, vol. 306, n° 5695, p. 485-7. doi: 10.1126/science.1099288 https://archive-ouverte.unige.ch/unige:26048

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Deposited on : 2013-01-30

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