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Title

Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

Authors
Ryffel, Bernhard
Rose, Stéphanie
Frémond, Cécile
Quesniaux, Valérie F
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Published in The Journal of Infectious Diseases. 2009, vol. 199, no. 7, p. 1053-63
Abstract Tumor necrosis factor (TNF) is associated with the development of inflammatory pathologies. Antibodies and soluble TNF (solTNF) receptors that neutralize excessive TNF are effective therapies for inflammatory and autoimmune diseases. However, clinical use of TNF inhibitors is associated with an increased risk of infections.
Keywords AnimalsCell LineDrug-Induced Liver InjuryImmunoglobulin G/pharmacologyImmunosuppressive Agents/pharmacologyLipopolysaccharides/toxicityLiver Diseases/prevention & controlLung/pathologyMiceMice, Inbred C57BLMice, KnockoutMycobacterium bovis/immunologyMycobacterium tuberculosis/immunologyReceptors, Tumor Necrosis FactorTuberculosis/immunology/pathologyTumor Necrosis Factor-alpha/antagonists & inhibitors/pharmacology/physiology
Identifiers
PMID: 19222369
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Article (Published version) (760 Kb) - public document Free access
Structures
Research groups Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)
Pneumologie Clinique (576)
Projects FNS: 3200A0-118196
TB REACT
Citation
(ISO format)
OLLEROS, Maria-Luisa et al. Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. In: The Journal of Infectious Diseases, 2009, vol. 199, n° 7, p. 1053-63. https://archive-ouverte.unige.ch/unige:25862

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Deposited on : 2013-01-23

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