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Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis |
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Authors | ![]() | |
Published in | The journal of infectious diseases. 2009, vol. 199, no. 7, p. 1053-63 | |
Abstract | Tumor necrosis factor (TNF) is associated with the development of inflammatory pathologies. Antibodies and soluble TNF (solTNF) receptors that neutralize excessive TNF are effective therapies for inflammatory and autoimmune diseases. However, clinical use of TNF inhibitors is associated with an increased risk of infections. | |
Keywords | Animals — Cell Line — Drug-Induced Liver Injury — Immunoglobulin G/pharmacology — Immunosuppressive Agents/pharmacology — Lipopolysaccharides/toxicity — Liver Diseases/prevention & control — Lung/pathology — Mice — Mice, Inbred C57BL — Mice, Knockout — Mycobacterium bovis/immunology — Mycobacterium tuberculosis/immunology — Receptors, Tumor Necrosis Factor — Tuberculosis/immunology/pathology — Tumor Necrosis Factor-alpha/antagonists & inhibitors/pharmacology/physiology | |
Identifiers | DOI: 10.1086/597204 PMID: 19222369 | |
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Research groups | Pneumologie Clinique (576) Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500) | |
Projects | Swiss National Science Foundation: 3200A0-118196 Autre: TB REACT | |
Citation (ISO format) | OLLEROS, Maria-Luisa et al. Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. In: The Journal of infectious diseases, 2009, vol. 199, n° 7, p. 1053-63. doi: 10.1086/597204 https://archive-ouverte.unige.ch/unige:25862 |