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Scientific article
Open access
English

Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

Published inThe Journal of infectious diseases, vol. 199, no. 7, p. 1053-1063
Publication date2009
Abstract

Tumor necrosis factor (TNF) is associated with the development of inflammatory pathologies. Antibodies and soluble TNF (solTNF) receptors that neutralize excessive TNF are effective therapies for inflammatory and autoimmune diseases. However, clinical use of TNF inhibitors is associated with an increased risk of infections.

Keywords
  • Animals
  • Cell Line
  • Drug-Induced Liver Injury
  • Immunoglobulin G/pharmacology
  • Immunosuppressive Agents/pharmacology
  • Lipopolysaccharides/toxicity
  • Liver Diseases/prevention & control
  • Lung/pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mycobacterium bovis/immunology
  • Mycobacterium tuberculosis/immunology
  • Receptors, Tumor Necrosis Factor
  • Tuberculosis/immunology/pathology
  • Tumor Necrosis Factor-alpha/antagonists & inhibitors/pharmacology/physiology
Funding
  • Swiss National Science Foundation - 3200A0-118196
  • Autre - TB REACT
Citation (ISO format)
OLLEROS, Maria-Luisa et al. Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. In: The Journal of infectious diseases, 2009, vol. 199, n° 7, p. 1053–1063. doi: 10.1086/597204
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0022-1899
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196downloads

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