Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

Olleros, Maria-Luisa; Vesin, Marie-Dominique; Fotio Lambou, Agathe; Janssens, Jean-Paul; Ryffel, Bernhard; Rose, Stéphanie; Frémond, Cécile; Quesniaux, Valérie F; Szymkowski, David E; Garcia, Irène

doi:10.1086/597204

Scientific article

English

Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

ContributorsOlleros, Maria-Luisa; Vesin, Marie-Dominique; Fotio Lambou, Agathe; Janssens, Jean-Paul; Ryffel, Bernhard; Rose, Stéphanie; Frémond, Cécile; Quesniaux, Valérie F; Szymkowski, David E; Garcia, Irène

Published inThe Journal of infectious diseases, vol. 199, no. 7, p. 1053-1063

Publication date2009

Abstract

Tumor necrosis factor (TNF) is associated with the development of inflammatory pathologies. Antibodies and soluble TNF (solTNF) receptors that neutralize excessive TNF are effective therapies for inflammatory and autoimmune diseases. However, clinical use of TNF inhibitors is associated with an increased risk of infections.

Keywords

Animals
Cell Line
Drug-Induced Liver Injury
Immunoglobulin G/pharmacology
Immunosuppressive Agents/pharmacology
Lipopolysaccharides/toxicity
Liver Diseases/prevention & control
Lung/pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mycobacterium bovis/immunology
Mycobacterium tuberculosis/immunology
Receptors, Tumor Necrosis Factor
Tuberculosis/immunology/pathology
Tumor Necrosis Factor-alpha/antagonists & inhibitors/pharmacology/physiology

Affiliation entities

Research groups

Funding

Swiss National Science Foundation - 3200A0-118196
Autre - TB REACT

Citation (ISO format)

OLLEROS, Maria-Luisa et al. Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. In: The Journal of infectious diseases, 2009, vol. 199, n° 7, p. 1053–1063. doi: 10.1086/597204

Article (Published version)

Identifiers

PID : unige:25862
DOI : 10.1086/597204
PMID : 19222369

Journal ISSN0022-1899

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Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

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