Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

Olleros, Maria-Luisa; Vesin, Marie-Dominique; Fotio Lambou, Agathe; Janssens, Jean-Paul; Ryffel, Bernhard; Rose, Stéphanie; Frémond, Cécile; Quesniaux, Valérie F; Szymkowski, David E; Garcia, Irène

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Title		Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis
Authors		Olleros, Maria-Luisa Vesin, Marie-Dominique Fotio Lambou, Agathe Janssens, Jean-Paul Ryffel, Bernhard Rose, Stéphanie Frémond, Cécile Quesniaux, Valérie F Szymkowski, David E Garcia, Irène show all authors [1 - 10]
Published in		The Journal of Infectious Diseases. 2009, vol. 199, no. 7, p. 1053-63
Abstract		Tumor necrosis factor (TNF) is associated with the development of inflammatory pathologies. Antibodies and soluble TNF (solTNF) receptors that neutralize excessive TNF are effective therapies for inflammatory and autoimmune diseases. However, clinical use of TNF inhibitors is associated with an increased risk of infections.
Keywords		Animals — Cell Line — Drug-Induced Liver Injury — Immunoglobulin G/pharmacology — Immunosuppressive Agents/pharmacology — Lipopolysaccharides/toxicity — Liver Diseases/prevention & control — Lung/pathology — Mice — Mice, Inbred C57BL — Mice, Knockout — Mycobacterium bovis/immunology — Mycobacterium tuberculosis/immunology — Receptors, Tumor Necrosis Factor — Tuberculosis/immunology/pathology — Tumor Necrosis Factor-alpha/antagonists & inhibitors/pharmacology/physiology
Identifiers		DOI: 10.1086/597204 PMID: 19222369
Full text		Article (Published version) (760 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups		Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500) Pneumologie Clinique (576)
Projects		FNS: 3200A0-118196 TB REACT
Citation (ISO format)		OLLEROS, Maria-Luisa et al. Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. In: The Journal of Infectious Diseases, 2009, vol. 199, n° 7, p. 1053-63. https://archive-ouverte.unige.ch/unige:25862