UNIGE document Scientific Article
previous document  unige:25744  next document
add to browser collection
Title

Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection

Authors
Haas, Anna
Zimmermann, Kathrin
Graw, Frederik
Slack, Emma
Rusert, Peter
Ledergerber, Bruno
Bossart, Walter
Weber, Rainer
show hidden authors show all authors [1 - 16]
CollaborationWith : Posfay Barbe, Klara / Wyler, Claire-Anne
Published in Gut. 2011, vol. 60, no. 11, p. 1506-19
Abstract Human systemic antibody responses to commensal microbiota are not well characterised during health and disease. Of particular interest is the analysis of their potential modulation caused by chronic HIV-1 infection which is associated with sustained enteropathy and systemic B cell disturbances reflected by impaired B cell responses and chronic B cell hyperactivity. The mechanisms underlying B cell hyperactivation and the specificities of the resulting hypergammaglobulinaemia are only poorly understood.
Keywords AdultAgedAnti-Retroviral Agents/therapeutic useAntibodies, Bacterial/bloodAntibody SpecificityB-Lymphocytes/immunologyChronic DiseaseCoinfection/immunologyFemaleFlow Cytometry/methodsHIV Enteropathy/drug therapy/immunologyHIV-1HumansHypergammaglobulinemiaImmunity, Mucosal/immunologyInflammatory Bowel Diseases/immunologyIntestinal Mucosa/immunology/microbiologyMaleMiddle Aged
Identifiers
PMID: 21515549
Full text
Article (Published version) (1.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Unité HIV (46)
Citation
(ISO format)
HAAS, Anna et al. Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection. In: Gut, 2011, vol. 60, n° 11, p. 1506-19. doi: 10.1136/gut.2010.224774 https://archive-ouverte.unige.ch/unige:25744

411 hits

0 download

Update

Deposited on : 2013-01-21

Export document
Format :
Citation style :