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Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection

Haas, Anna
Zimmermann, Kathrin
Graw, Frederik
Slack, Emma
Rusert, Peter
Ledergerber, Bruno
Bossart, Walter
Weber, Rainer
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CollaborationWith : Posfay Barbe, Klara / Wyler, Claire-Anne
Published in Gut. 2011, vol. 60, no. 11, p. 1506-19
Abstract Human systemic antibody responses to commensal microbiota are not well characterised during health and disease. Of particular interest is the analysis of their potential modulation caused by chronic HIV-1 infection which is associated with sustained enteropathy and systemic B cell disturbances reflected by impaired B cell responses and chronic B cell hyperactivity. The mechanisms underlying B cell hyperactivation and the specificities of the resulting hypergammaglobulinaemia are only poorly understood.
Keywords AdultAgedAnti-Retroviral Agents/therapeutic useAntibodies, Bacterial/bloodAntibody SpecificityB-Lymphocytes/immunologyChronic DiseaseCoinfection/immunologyFemaleFlow Cytometry/methodsHIV Enteropathy/drug therapy/immunologyHIV-1HumansHypergammaglobulinemiaImmunity, Mucosal/immunologyInflammatory Bowel Diseases/immunologyIntestinal Mucosa/immunology/microbiologyMaleMiddle Aged
PMID: 21515549
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Research groups Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Unité HIV (46)
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HAAS, Anna et al. Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection. In: Gut, 2011, vol. 60, n° 11, p. 1506-19. doi: 10.1136/gut.2010.224774 https://archive-ouverte.unige.ch/unige:25744

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Deposited on : 2013-01-21

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