Scientific article

Systemic inflammation disrupts the developmental program of white matter

Published inAnnals of neurology, vol. 70, no. 4, p. 550-565
Publication date2011

Perinatal inflammation is a major risk factor for neurological deficits in preterm infants. Several experimental studies have shown that systemic inflammation can alter the programming of the developing brain. However, these studies do not offer detailed pathophysiological mechanisms, and they rely on relatively severe infectious or inflammatory stimuli that most likely do not reflect the levels of systemic inflammation observed in many human preterm infants. The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development.

  • Animals
  • Animals, Newborn
  • Brain/drug effects/growth & development/pathology
  • Inflammation/pathology
  • Injections, Intraperitoneal
  • Interleukin-1beta/administration & dosage/pharmacology
  • Magnetic Resonance Imaging
  • Mice
  • Nerve Fibers, Myelinated/drug effects/pathology
  • Oligodendroglia/drug effects/pathology
Citation (ISO format)
FAVRAIS, Géraldine et al. Systemic inflammation disrupts the developmental program of white matter. In: Annals of neurology, 2011, vol. 70, n° 4, p. 550–565. doi: 10.1002/ana.22489
Main files (1)
Article (Published version)
ISSN of the journal0364-5134

Technical informations

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First validation12/17/2012 1:28:00 PM
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