Scientific article
English

Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep

Published inAnnals of neurology, vol. 70, no. 5, p. 846-856
Publication date2011
Abstract

Preterm infants exhibit chronic deficits in white matter (WM) and cortical maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors contributing to cortical changes are largely unknown. We examined the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalography (EEG), and histopathology in fetal sheep at preterm human equivalent age.

Keywords
  • Animals
  • Cerebral Cortex/drug effects/growth & development/pathology/physiopathology
  • Electroencephalography
  • Female
  • Fetus/drug effects/pathology/physiopathology
  • Lipopolysaccharides/administration & dosage/toxicity
  • Magnetic Resonance Imaging
  • Nerve Fibers, Myelinated/drug effects/pathology
  • Pregnancy
  • Prenatal Exposure Delayed Effects/pathology/physiopathology
  • Sheep
Citation (ISO format)
DEAN, Justin M et al. Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep. In: Annals of neurology, 2011, vol. 70, n° 5, p. 846–856. doi: 10.1002/ana.22480
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0364-5134
624views
0downloads

Technical informations

Creation13/12/2012 14:48:00
First validation13/12/2012 14:48:00
Update time14/03/2023 19:58:33
Status update14/03/2023 19:58:33
Last indexation30/10/2024 08:32:43
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack