Scientific article

Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep

Published inAnnals of neurology, vol. 70, no. 5, p. 846-856
Publication date2011

Preterm infants exhibit chronic deficits in white matter (WM) and cortical maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors contributing to cortical changes are largely unknown. We examined the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalography (EEG), and histopathology in fetal sheep at preterm human equivalent age.

  • Animals
  • Cerebral Cortex/drug effects/growth & development/pathology/physiopathology
  • Electroencephalography
  • Female
  • Fetus/drug effects/pathology/physiopathology
  • Lipopolysaccharides/administration & dosage/toxicity
  • Magnetic Resonance Imaging
  • Nerve Fibers, Myelinated/drug effects/pathology
  • Pregnancy
  • Prenatal Exposure Delayed Effects/pathology/physiopathology
  • Sheep
Citation (ISO format)
DEAN, Justin M et al. Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep. In: Annals of neurology, 2011, vol. 70, n° 5, p. 846–856. doi: 10.1002/ana.22480
Main files (1)
Article (Published version)
ISSN of the journal0364-5134

Technical informations

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